Results 101 to 110 of about 160,127 (291)

The northern sector of the last British ice sheet : maximum extent and demise [PDF]

, 2008
Strongly divided opinion has led to competing, apparently contradictory, views on the timing, extent, flow configuration and decay mechanism of the last British Ice Sheet.
Bradwell, Tom, Stoker, Martyn, Golledge, Nicholas, Wilson, Christian Kverneland, Merritt, Jon, Long, David, Everest, Jeremy, Hestvik, O.B., Stevenson, Alan, Hubbard, Alun, Finlayson, Andrew, Mathers, Hannah   +11 more
core   +2 more sources

Characterization of Clinical Phenotype to Glial Fibrillary Acidic Protein Concentrations in Alexander Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To determine the concentration of glial fibrillary acidic protein (GFAP) in cerebrospinal fluid (CSF) and plasma in Alexander disease (AxD) and whether GFAP levels are predictive of disease phenotypes. Methods CSF and plasma were collected (longitudinally when available) from AxD participants and non‐AxD controls.
Amy T. Waldman, Asako Takanohashi, Joshua Y. Joung, Geraldine W. Liu, Kaley Arnold, Amy Pizzino, Walter Faig, Sarah Woidill, Sona Narula, Adeline L. Vanderver   +9 more
wiley   +1 more source

Last Glacial Maximum cooling induced positive moisture balance and maintained stable human populations in Australia

Communications Earth & Environment
Long-standing interpretations of the Last Glacial Maximum (21,000 ± 2000 years ago) in Australia suggest that the period was extremely cold and arid, during which the Indo-Australian summer monsoon system collapsed, and human populations declined and ...
Haidee Cadd, Alan N. Williams, Wanchese M. Saktura, Tim J. Cohen, Scott D. Mooney, Chengfei He, Bette Otto‐Bliesner, Chris S. M. Turney   +7 more
doaj   +1 more source

Potential atmospheric impact of the Toba Mega‐Eruption ∼71,000 years ago [PDF]

, 1996
An ∼6‐year long period of volcanic sulfate recorded in the GISP2 ice core about 71,100 ± 5000 years ago may provide detailed information on the atmospheric and climatic impact of the Toba mega‐eruption. Deposition of these aerosols occur at the beginning
Mayewski, Paul A., Meeker, L. David, Taylor, Kendrick C., Twickler, Mark S., Whitlow, Sallie I., Zielinski, Gregory A.   +5 more
core   +3 more sources

Varied Response of Western Pacific Hydrology to Climate Forcings over the Last Glacial Period [PDF]

, 2013
Atmospheric deep convection in the west Pacific plays a key role in the global heat and moisture budgets, yet its response to orbital and abrupt climate change events is poorly resolved.
Adkins, Jess F., Carolin, Stacy A., Clark, Brian, Cobb, Kim M., Conroy, Jessica L., Lejau, Syria, Malang, Jenny, Tuen, Andrew A.   +7 more
core   +1 more source

Rapid environmental changes in southern Europe during the last glacial period

Nature, 1999
Oxygen-isotope records from Greenland ice cores1,2 indicate numerous rapid climate fluctuations during the last glacial period. North Atlantic marine sediment cores show comparable variability in sea surface temperature and the deposition of ice-rafted debris3,4,5.
Allen, Judy R. M., Brandt, Ute, Brauer, Achim, Hubberten, Hans-Wolfgang, Huntley, Brian, Keller, Jörg, Kraml, Michael, Mackensen, Andreas, Mingram, Jens, Negendank, Jörg F. W., Nowaczyk, Norbert R., Oberhänsli, Hedi, Watts, William A., Wulf, Sabine, Zolitschka, Bernd   +14 more
openaire   +4 more sources

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

Vegetation and climate reconstruction during the Last Interglacial Complex: the pollen record of Lake Ohrid (Albania/Fyrom), the oldest European lake [PDF]

, 2017
This thesis is focussed on the palaeonvironmental and climatic changes occurred during the period between 130 and 70 ka (including the whole Last Interglacial Complex), with the aims to investigate the long-term climate variability on environment, on the
SINOPOLI, GAIA
core  

Pre-late Devensian high-arctic marine deposits in SW Scotland [PDF]

, 2010
We present new interpretations of Digital Elevation Model (DEM) data and marine fossils collected from three sites on the Rhins of Galloway which, contrary to recent proposals, suggest that the landforms and deposits of the region do not represent ...
CHARLESWORTH, KERR, SHOTTON
core   +2 more sources

Effect of Foot Orthoses on Midfoot Pain and the Volume of Bone Marrow Lesions in the Midfoot: A Randomized Mechanism of Action Study

Arthritis Care &Research, EarlyView.
Objective Foot orthoses are thought to improve pain by potentially modifying internal mechanical forces. To test this, we explored whether foot orthoses can modify patterns of bone marrow lesions (BMLs) in people with midfoot pain. Methods Forty‐two people were recruited with midfoot pain, and magnetic resonance imaging–confirmed midfoot BMLs ...
Jill Halstead, Anne‐Maree Keenan, Philip G. Conaghan, Dennis McGonagle, Anthony C. Redmond   +4 more
wiley   +1 more source