Results 131 to 140 of about 5,862,672 (337)
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
What's new in trachoma control?
Community Eye Health Journal, 2004 Progress towards elimination of blinding trachoma Ten years after the Community Eye Health Journal first devoted an entire issue to trachoma (Vol. 7, Issue 14), and five years since its last trachoma-focused edition (Vol.
Jacob Kumaresan
doaj
Iran’s nuclear program - and the costs of stopping it [PDF]
This paper considers the positions of US and Israeli leaders, the current negotiations, and the possible drivers for a military strike against Iran. Over the last six months, the prospects of an Israeli preemptive strike against the Iranian nuclear ...
Rod Lyon
core
PICALM::MLLT10 translocated leukemia
FEBS Letters, EarlyView.This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen +7 more
wiley +1 more source
Ecoso exchange newsletter : ecological, sociological and political discourse 2/42; Dec. 1996 [PDF]
, 1996 This issue of Ecoso is mainly about citizenship and the labour movement. Contents: Page 1. A Charter for All Children 2. Unions and Citizenship by Peter Gibbons (AMEU) 4. Unions and Citizenship by Jenny Drabby (VTHC) 5.
core
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
Last issue of journal of chemical biology. [PDF]
J Chem Biol, 2017 Woscholski R, Larijani B.
europepmc +1 more source