Results 121 to 130 of about 440,001 (300)

XMM-Newton observations of the sigma Ori cluster. II. Spatial and spectral analysis of the full EPIC field

, 2005
We present the results of an XMM-Newton observation of the young (~2-4 Myr) cluster around the hot star sigma Orionis. In a previous paper we presented the analysis of the RGS spectrum of the central hot star; here we discuss the results of the analysis ...
Argiroffi, Argiroffi, Baraffe, Barrado y Navascués, Barrado y Navascués, Barrado y Navascués, Berghöfer, Brown, Burningham, Béjar, Béjar, Béjar, Caballero, Damiani, E. Franciosini, Favata, Feigelson, Feigelson, Flaccomio, Flaccomio, Flaccomio, Flaccomio, Gagné, Garmire, Garmire, Getman, Hasinger, Hesser, Imanishi, Imanishi, J. Sanz-Forcada, Kastner, Kastner, Kenyon, Kenyon, Lavalley, Lee, Leggett, Martín, Mokler, Muzerolle, Neuhäuser, Oliveira, Oliveira, Oliveira, Ozawa, Pallavicini, Preibisch, Preibisch, Preibisch, R. Pallavicini, Ramírez, Randich, Sanz-Forcada, Scelsi, Schmitt, Scholz, Sherry, Siess, Skinner, Stassun, Stelzer, Stelzer, Stelzer, Stelzer, Tozzi, Walter, Weaver, Zapatero Osorio, Zapatero Osorio   +69 more
core   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Tidal Synchronization of TESS Eclipsing Binaries

The Astrophysical Journal
Tidal synchronization plays a fundamental role in the evolution of binary star systems. However, key details such as the timescale of synchronization, efficiency of tidal dissipation, rotation period, and dependence on stellar mass are not well ...
Marshall Hobson-Ritz, Jessica Birky, Leah Peterson, Peter Gwartney, Rachel Wong, John Delker, Tyler Gordon, Samantha Gilbert, James R. A. Davenport, Rory Barnes   +9 more
doaj   +1 more source

Tales of stellar and binary coevolution, told by stellar oscillations

Astronomy & Astrophysics
Context. Red giants are increasingly used as stellar population tracers due to their well-understood evolution and the availability of asteroseismic observables. However, stellar binarity can alter observable properties and introduce strong biases. Aims.
Beck Paul G.
doaj   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

The Appearance and Disappearance of Exocomet Gas Absorption

Advances in Astronomy, 2015
CaII K-line (3933 Å) absorption profiles observed towards 15 A-type and two B-type stars with known (or suspected) debris disks, in addition to archival spectral data for three A-type stars, are presented.
Barry Y. Welsh, Sharon L. Montgomery
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

High Proper Motion Discoveries from the UKIRT Hemisphere Survey

The Astronomical Journal
We used the third data release of the UKIRT Hemisphere Survey to locate previously unrecognized high proper motion objects. We identify a total of 127 new discoveries with total proper motions ≳300 mas yr ^−1 .
Wings Zhang, Adam C. Schneider, Thomas P. Bickle, Adam J. Burgasser, Emma Softich, Federico Marocco, Daniella Bardalez Gagliuffi, Jacqueline K. Faherty, Aaron M. Meisner, J. Davy Kirkpatrick, Marc J. Kuchner, Martin Kabatnik, Frank Kiwy, Arttu Sainio, Jörg Schümann, Karl Selg-Mann, Nikolaj Stevnbak Andersen, Bruce Baller, Paul Beaulieu, John Bell, Dan Caselden, Guillaume Colin, Alexandru Dereveanco, Christoph Frank, Konstantin Glebov, Léopold Gramaize, Leslie K. Hamlet, David W. Martin, William Pendrill, Stéphane Perlin, Andres Stenner, Christopher Tanner, Melina Thévenot, Vinod Thakur   +33 more
doaj   +1 more source