Results 121 to 130 of about 180,240 (308)

Evidence for late-glacial oceanic carbon redistribution and discharge from the Pacific Southern Ocean. [PDF]

Nat Commun, 2022
Iwasaki S, Lembke-Jene L, Nagashima K, Arz HW, Harada N, Kimoto K, Lamy F.   +6 more
europepmc   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Use of δ¹⁸O_atm in dating a Tibetan ice core record of Holocene/Late Glacial climate. [PDF]

Proc Natl Acad Sci U S A, 2022
Thompson LG, Severinghaus JP, Yao T, Davis ME, Mosley-Thompson E, Beaudon E, Sierra-Hernández MR, Porter SE.   +7 more
europepmc   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Reconstructing social networks of Late Glacial and Holocene hunter-gatherers to understand cultural evolution. [PDF]

Philos Trans R Soc Lond B Biol Sci, 2022
Romano V, Lozano S, Fernández-López de Pablo J.   +2 more
europepmc   +1 more source

Late-Glacial Cwm Glaciers In Wales [PDF]

Journal of Glaciology, 1957
Abstract The evidence for the existence of small glaciers in the cwms of the Caernarvonshire mountains during the Late-glacial Period is presented, and by an analysis of their distribution some of the factors responsible for their formation are deduced. These were primarily protection from insolation, drifting of snow into the cirques
openaire   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Floodplain environmental change during the younger dryas and holocene: Evidence from the lower kennet valley, south central England [PDF]

, 2006
Many lowland rivers across northwest Europe exhibit broadly similar behavioural responses to glacial-interglacial transitions and landscape development. Difficulties exist in assessing these, largely because the evidence from many rivers remains limited
Collins, PEF, Fenwick, IM, Keith-Lucas, DM, Worsley, P   +3 more
core  

Palynological data for the Late Glacial and Holocene (14.5-0 ka BP) from Füramoos, Southern Germany. [PDF]

Data Brief, 2021
Kern OA, Koutsodendris A, Pross J.
europepmc   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source