Results 111 to 120 of about 180,240 (308)

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

LATE GLACIAL AND HOLOCENE ENVIRONMENTAL CHANGE INFERRED FROM THE PÁRAMO OF CAJANUMA IN THE PODOCARPUS NATIONAL PARK, SOUTHERN ECUADOR

Caldasia, 2014
To reconstruct the environmental history including vegetation, fire and climate dynamics, from the Cajanuma valley area ( 3285 m elevation) in the Podocarpus National Park, southern Ecuador , we address the following major research question: (1) How did ...
ANDREA VILLOTA, HERMANN BEHLING
doaj   +1 more source

Summer paleohydrology during the Late Glacial and Early Holocene based on δ²H and δ¹⁸O from Bichlersee, Bavaria. [PDF]

Sci Rep, 2023
Prochnow M, Strobel P, Bliedtner M, Struck J, Bittner L, Szidat S, Salazar G, Schneider H, Acharya S, Zech M, Zech R.   +10 more
europepmc   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Investigation of the Geological, Mineralogical, and Geochemical Contents of the Sedimentary Fills in the Northern Area of the Quaternary-Aged Bor Basin (Niğde/Turkey): Implications for Sediment Source and Paleoclimates

Quaternary
In the northern part of the Niğde (Central Anatolian) Quaternary Bor Basin, stratigraphic sections P1 and P2 were sampled, reaching depths of 11 m and 25 m.
Alperen Sahinoglu, Ali Gürel
doaj   +1 more source

A Continuous Centennial Late Glacial-Early Holocene (15-10 cal kyr BP) Palynological Record from the Iberian Pyrenees and Regional Comparisons. [PDF]

Plants (Basel), 2023
Rull V, Blasco A, Calero MÁ, Blaauw M, Vegas-Vilarrúbia T.   +4 more
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Glacial events in Carboniferous sequences from Paganzo and Río Blanco Basins (Northwest Argentina): Palynology and depositional setting

Geologica Acta, 2011
The age and depositional setting of two glacial events recognized in the western basins of Argentina are discussed in this paper. The older one corresponds to diamictites identified in the upper member of the Cortaderas Formation (Visean, Río Blanco ...
V.S. PÉREZ LOINAZE, C.O. LIMARINO, S.N. CÉSARI   +2 more
doaj  

A radiocarbon spike at 14 300 cal yr BP in subfossil trees provides the impulse response function of the global carbon cycle during the Late Glacial. [PDF]

Philos Trans A Math Phys Eng Sci, 2023
Bard E, Miramont C, Capano M, Guibal F, Marschal C, Rostek F, Tuna T, Fagault Y, Heaton TJ.   +8 more
europepmc   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source