Results 201 to 210 of about 1,748,641 (295)

Postglacial ecosystem development of a hydrothermal landscape in Yellowstone National Park. [PDF]

Proc Natl Acad Sci U S A
Whitlock C, Schiller CM, Hostetler SW, Hurwitz S, Alt M, Brown SR, Harrison LN, Alder JR, Busch K, Shelly J, McWethy DB.   +10 more
europepmc   +1 more source

Dual‐Mode Gripper With Suction and Shape‐Adaptive Freezing Grasps

Advanced Robotics Research, EarlyView.
This study presents a dual‐mode robotic gripper that combines vacuum suction with a shape‐adaptive freezing grasp. The freezing mode uses a compliant rubber membrane, a sprayed water layer, and dry‐ice powder to generate ice‐mediated adhesion while conforming to complex geometries.
Takuma Yanagisawa, Toshihiro Nishimura, Yosuke Suzuki, Tokuo Tsuji, Tetsuyou Watanabe   +4 more
wiley   +1 more source

Reduced N₂ fixation in the tropical Atlantic Ocean during the warm late Pliocene. [PDF]

Nat Commun
Yehudai M, Farmer JR, Straub M, Studer AS, Oesch L, Creel RC, Schiebel R, Auderset A, Lawrence K, Ogretmen N, Haug GH, Sigman DM, Martínez-García A.   +12 more
europepmc   +1 more source

TWO LATE-GLACIAL DEPOSITS IN SOUTHERN CONNECTICUT [PDF]

Proceedings of the National Academy of Sciences, 1956
openaire   +2 more sources

Dual Role of Tamoxifen in Enhancing STING and CEACAM1 Expression to Prime a Favorable Tumor Microenvironment for Anti‐TIM3 Immunotherapy

Advanced Science, EarlyView.
Anti‐PD‐1/PD‐L1 blockade has revolutionized cancer immunotherapy, but is ineffective against endocrine‐treated (i.e., Tamoxifen), relapsed ER+ breast cancer (BC) patients. This study provides insight into the sub‐optimal response of ER+BCs to anti‐PD‐1/PD‐L1 blockade – highlighting the induction of STING and the CEACAM1/TIM3 axis after chronic ...
Marvin Angelo E Aberin, Saurabh Singh, Soumya Chatterjee, Guang‐Zhi Sui, Yi‐Fu Wang, Ya‐Ting Lu, Yu‐Ling Lee, Kun‐Yuan Lin, Joy Khag, Ta‐Yu Liu, Shao‐Han Chang, Wai‐Mui Cheung, Hsiao‐Chin Hong, Ren‐Jun Hsu, Chen‐Yang Shen, Chia‐Wei Li, Weng‐Lang Yang, Yao‐Ming Chang, Shih‐Yu Chen, Chandan Guha, Shu‐Ping Wang   +20 more
wiley   +1 more source

Rab1A Promotes Hepatic Steatosis by Suppressing Mitophagy via the Raf‐1/ERK1/2/PINK1 Signaling Axis

Advanced Science, EarlyView.
Why does fat accumulate in the liver? Our study reveals Rab1A as the molecular switch that silences the cell's mitochondrial cleanup crew. Turning Rab1A off reactivates mitophagy, clears excess fat, and reverses fatty liver disease in mice—offering a promising new therapeutic target for MASLD, a growing global health challenge.
Li Zhang, Jianhua Li, Huilu Zhang, Qi Qin, Yichen Huang, Xiaofan Tian, Chao Sun, Binbin Li, Zhengxin Wang, Xin Zhang   +9 more
wiley   +1 more source

Annual-resolution evidence for aridity spikes at the onset of the Last Glacial Inception in an Eifel maar lake sediment. [PDF]

Sci Rep
Sirocko F, Krebsbach F, Forster C, Dreher F, Grosjean M, Silva L, Riechelmann DFC, Seelos K, Schiebel R.   +8 more
europepmc   +1 more source

Modulation of miR‐23b Wnt/β‐catenin Axis Strengthens Endothelial Barrier Properties

Advanced Science, EarlyView.
Early blood‐brain barrier (BBB) disruption contributes to stroke and CNS disease pathology. miR‐23b was identified as a regulator of BBB integrity in brain endothelial cells. Inhibition of miR‐23b enhanced barrier‐associated properties, promoted repair‐related signaling, and reduced BBB leakage in experimental stroke models, supporting further ...
Victor Anthony Martinez, Rose E. Presby, Sara Nakanishi, Pallavi Gaur, Ugur Akcan, Johannes Daugaard Krog, Iben Daugaard Krog, Lipi Das, David S. Johnson, Danny Jamoul, Douglas Jury, Brian Lawson, Jacob Körbelin, Lewis M. Brown, Vilas Menon, Dritan Agalliu, Irene Munk Pedersen   +16 more
wiley   +1 more source

Climate and Fuel Controls on North American Paleofires: Smoldering to Flaming in the Late-glacial-Holocene Transition. [PDF]

Sci Rep, 2016
Han YM, Peteet DM, Arimoto R, Cao JJ, An ZS, Sritrairat S, Yan BZ.   +6 more
europepmc   +1 more source

Innate Immunocompetent hiPSC‐Derived Neurospheroids Capture Early CNS Responses to rAAV

Advanced Science, EarlyView.
Knowledge of human CNS immune responses to AAV‐based gene therapies remains limited due to the lack of immune‐competent human models. Here, a hiPSC‐derived 3D neuroimmune platform integrating neurospheroids and microglia is established using stirred‐tank bioreactors.
Catarina M. Gomes, Gabriela Silva, Mafalda Aleixo, Marta Gomes, Daniel Simão, Stephan J. Holtkamp, Diana D. Lobo, Pradeep Harish, Rosalind Jenkins, Lekh N. Dahal, Rui J. Nobre, Luís de Pereira de Almeida, Mark Trautwein, Paula M. Alves, Catarina Brito   +14 more
wiley   +1 more source