Results 51 to 60 of about 38,197 (265)
Late Quaternary glacial phases in the Iberian Peninsula
Earth-Science Reviews, 2019 The only glaciers existing today in the Iberian Peninsula are small features located in the Pyrenees, though their number and extension has undergone significant changes over the Late Quaternary. The wide range of glacial landforms and deposits distributed across different Iberian ranges suggests the occurrence of several past periods with larger ...Oliva, M., Palacios, D., Fernández-Fernández, J.M., Rodr'Iguez-Rodr'Iguez, L., Garc'Ia-Ruiz, J.M., Andrés, N., Carrasco, R.M., Pedraza, J., Pérez-Alberti, A., Valcárcel, M., Hughes, P.D. +10 moreopenaire +8 more sourcesEvolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function
FEBS Open Bio, EarlyView.We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill +4 morewiley +1 more sourceGeomorphology of the Kaikoura area
, 1968 The major physiographic units in the Kaikoura area are the Peninsula Block, Beach Ridges and Raised Beaches, Hard Rock Areas and the Alluvial Fans. Erosion of the Seaward Kaikoura Mountains and the transfer of the debris to the sea by fan streams have ...Chandra, Satishcore +1 more sourceA comparison of climate simulations for the last glacial maximum with three different versions of the ECHAM model and implications for summer-green tree refugia [PDF]
, 2011 This is an open access article. The official link can be found below.Model simulations of the last glacial maximum (21 ± 2 ka) with the ECHAM3 T42 atmosphere-only, ECHAM5-MPIOM T31 atmosphere-ocean coupled and ECHAM5 T106 atmosphere-only models are ...Leroy, S.a.g., Mikolajewicz, U, Leroy, S. A. G., U. Mikolajewicz, Arpe, K, K. Arpe, Leroy, S., Arpe, K., S. A. G. Leroy, Leroy, SAG, Mikolajewicz, U. +10 morecore +1 more sourceSystemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum
FEBS Open Bio, EarlyView.Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim +6 morewiley +1 more sourceLarge‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco +11 morewiley +1 more sourceYIPFα1A expression is regulated by multilayered molecular mechanisms
FEBS Open Bio, EarlyView.YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura +2 morewiley +1 more sourceChanges in fire regimes since the last glacial maximum: an assessment based on a global synthesis and analysis of charcoal data [PDF]
, 2007 Fire activity has varied globally and continuously since the last glacial maximum (LGM) in response to long-term changes in global climate and shorter-term regional changes in climate, vegetation, and human land use.Prentice, I. C., Hallett, D. J., Minckley, T., Vescovi, Elisa, Edwards, M., Lynch, E, Harrison, S.P., Noti, Roland, Tinner, Willy, Camill, P, Lynch, J, Kong, Z. C., Daniau, A.L., Long, J., Bradshaw, Richard H.W., Larsen, C, Mayle, FE, Carcaillet, C, Zhao, Y, Williams, Nicola, Daniels, Mark, Tinner, W., Shuman, B. N., Toney, J., Takahara, H, Brown, K. J., Moreno, P. I., Haberle, Simon G., Pierce, Jennifer, Camill, P., Colombaroli, D, Mayle, Francis E., Nelson, M., Oswald, W, Newnham, R., Edwards, ME, Ballouche, A, Wang, XD, Goni, M, Prentice, IC, C. Whitlock, C., New, J., Foster, Douglas, Gaillard, M, Richard, Pierre J.H., Shuman, B, Oswald, W. Wyatt, Vescovi, E, Power, M. J., Kong, C., Newnham, Rewi M., Brown, Katherine, Bradshaw, R, Mensing, S., Newnham, R, Bradshaw, Richard H. W., Meeks, S., Briles, C, Gavin, D.G., Vandergoes, M, Daniau, A.-L., Higuera, P, Mayle, F. E., Umbanhowar, C, Harrison, P., Prentice, I.C., Higuera, P., Mayle, F.E., Rowe, C, Connor, S. E., Ali, A., Gaillard, Marie-José,, Marlon, Jenn, Daniels, M., Long, C.J., Zhang,, Y., Clark, Jim, Kaltenrieder, Petra, Zhang, Y, Behling, H, Gobet, E, Nelson, D, Bradshaw, RHW, Ballouche, A., Lynch, J., Bradshaw, R. H. W., Williams, N, Beer, R, Richard, Pierre J. H., Haberle, S, Ali, A. A., Vanniere, B, Foster, D., Anderson, Scott R.S., Horn, S, Urrego-Sanchez, D, Hallett, D, Power, M.J., Chu, G, Vescovi, E., Ali, A.A., Beer, Ruth, Moreno, P.I., Harrison, Sandy P., Anderson, R. Scott, Marlon, J., Chu, G.Q., Sanchez Goñi, M. F., Finsinger, W, Foster, D. R., Bartlein, P.J., Daniau, A, Ortiz, Natalie, Pierce, Jen, Ortiz, N, Wang, Xuking, Lynch, E. A., Thonicke, K, Bush, M., Haberle, Simon, Anderson, R., Bradshaw, H., Ali, Amna, Rowe, Cassandra, Harrison, S.P. Sandy, Long, C. J., Vanniere, Boris, Wilmshurst, Janet M., Prentice, I, Lynch, Jodi, Gaillard-Lemdahl, Marie-Jose, Foster, D, Richard, PJH, Gaillard, M.J., McGlone, Matt S., Gavin, D, Gaillard, Marie -Jose, Kennedy, L., Toney, Jaime, Gavin, D. G., Harrison, SP, Mayle, E., Kennedy, L, Harrison, Simon, Power, Mitch J., Hallett, D.J., Marlon, J, Bartlein, PJ, Richard, P.J.H., Hallett, DJ, McGlone, M, Prentice, C., Clark, J., Dodson, J., Behling, Hermann, Walsh, M, Ballouche, Aziz, Hope, G, Pierce, J., Hope, Geoffrey, Thonicke, Kirsten, Wilmshurst, J, Shuman, N., Edwards, M.E., Bartlein, P, Horn, S., Connor, S., Dodson, JR, Frechette, J., Richard, P, Toney, J.L., Zhao, Y., Thonicke, K., Zhang, Y., Connor, Stuart, Inoue, J, Inoue, J., Shuman, B.N., Kong, Z, Larsen, C., Mooney, Scott, Carcaillet, C., Brown, KJ, Zhao, Yong, Vandergoes, Marcus, Colombaroli, Daniele, Kong, ZC, Mohr, Jerry, Mohr, J, Nelson, DM, Cordova, C., Gaillard, M.-J., Behling, H., Frechette, J. D., Mooney, S, Ali, Adam A., Goni, MFS, Kennedy, Liz, Long, C, Edwards, M. E., New, J, Gobet, Erika, Brunelle, A, Prentice, Colin I.C., Whitlock, C, Daniau, AL, Richard, J., Zhang, JH, Lynch, E.A., Sanchez Goñi, M. F., Shuman, BN, Power, M, Pierce, J, Long, CJ, Mensing, S, Gaillard, J., Haberle, S., Brown, K.J., Hallett, D J, Zhang, J., Brown, J., Wang, Xu King, Whitlock, C., Daniels, M, Briles, C., Higuera, Philip, Chu, G. Q., Meeks, S, Minckley, T, Brunelle, A., Anderson, RS, Anderson, Richard, Beer, R., Bartlein, P. J., Sánchez Gonñi, M. F., Ortiz, N., Prentice, I. Colin, Power, Mitchell,, Hope, G., Zhao, Yan, Wilmshurst, Janet M, Nelson, D.M., Wilmshurst, J., Kaltenrieder, P, Rowe, C., Gavin, D., Anderson, R.S., Mohr, J., Mayle, F, Oswald, Wyatt, Sanchez Goñi, Maria Fernanda, Urrego-Sanchez, D. H., Clark, J, Daniau, L., Moreno, P I, Moreno, P., Ali, AA, Finsinger, Walter, Nelson, D. M., Vanniere, B., Cardova, C, Gobet, E., Kaltenrieder, P., McGlone, M., Tinner, W, Bartlein, J., Meyer, G., Noti, R., Zhang, J. H., GPWG, members, Moreno, PI, Meyer, G, Noti, R, Mooney, S., Connor, S, Mooney, SD, Umbanhowar, C., Chu, Guo Qiang, Frechette, J, Vandergoes, Marcus J., Daniau, A. L., Turney, Chris; id_orcid, Oswald, W., Urrego-Sanchez, D., Zhang, J.H., Colombaroli, D., Kong, Z.C., Power, MJ, Doughty, E, Dodson, John Richard, Walsh, M., Williams, N., Sanchez Goni, M., Vandergoes, M., Anderson, R. S., Harrison, S. P., Finsinger, W., Chu, GQ, Gaillard, MJ, Mooney, Scott D., Bush, M, Takahara, H., Urrego-Sanchez, D.H., Turney, CSM, Wang, X., Cordova, C, Inoue, Jun, Daniau, A. -L, Richard, P. J. H., Urrego-Sanchez, DH, Doughty, E., Gavin, DG, Sanchez Goñi, M.F., Lynch, E., Dodson, John, Zhang, Yanling, Marlon, Jenny, Chu, G., Bradshaw, R.H.W., Edwards, Meredith, Turney, C., Lynch, EA, Toney, J, Boltshauser-Kaltenrieder, Petra, Moreno, P, Turney, C, Brunelle, Andrea +326 morecore +1 more source