Results 21 to 30 of about 2,746,446 (292)

Discovery of a Cryptic Intermediate in Late Steps of Mithramycin Biosynthesis [PDF]

Angewandte Chemie, 2019
AbstractMtmOIV and MtmW catalyze the final two reactions in the mithramycin (MTM) biosynthetic pathway, the Baeyer–Villiger opening of the fourth ring of premithramycin B (PMB), creating the C3 pentyl side chain, strictly followed by reduction of the distal keto group on the new side chain. Unexpectedly this results in a C2 stereoisomer of mithramycin,
Ryan Wheeler, Xia Yu, Caixia Hou, Prithiba Mitra, Jhong‐Min Chen, Frank Herkules, Dmitri N. Ivanov, Oleg V. Tsodikov, Jürgen Rohr   +8 more
openaire   +2 more sources

La Segunda Muralla-Puente Lurín de Pachacamac durante los inicios de la conquista inca: interpretación de nuevos datos

Bulletin de l'Institut Français d'Études Andines, 2023
During the third and fourth epochs of the Middle Horizon, the sanctuary of Pachacamac began to have regional prestige that later increased in the Late Intermediate Period and Late Horizon.
Jesús A. Ramos Giraldo, Ponciano Paredes Botoni †   +1 more
doaj   +1 more source

Drosophila S2 cells are non-permissive for vaccinia virus DNA replication following entry via low pH-dependent endocytosis and early transcription. [PDF]

PLoS ONE, 2011
Vaccinia virus (VACV), a member of the chordopox subfamily of the Poxviridae, abortively infects insect cells. We have investigated VACV infection of Drosophila S2 cells, which are useful for protein expression and genome-wide RNAi screening. Biochemical
Zain Bengali, P S Satheshkumar, Zhilong Yang, Andrea S Weisberg, Nir Paran, Bernard Moss   +5 more
doaj   +1 more source

Sobre alfarería, cementerios, fases y procesos durante la prehistoria tardía del desierto de Atacama (800-1600 DC)

Estudios Atacameños, 2002
En este artículo se somete a revisión la problemática cultural y temporal de la prehistoria tardía del desierto de Atacama de acuerdo a un estudio sistemático y comparativo de la alfarería funeraria de las dos cuencas, San Pedro y el Loa, que componen ...
Mauricio Iván Uribe Rodríguez
doaj   +10 more sources

Transcatheter Aortic Valve Replacement–Associated Infective Endocarditis: Comparison of Early, Intermediate, and Late-Onset Cases

Structural Heart, 2022
Background: Transcatheter aortic valve replacement–associated infective endocarditis (TAVR-IE) is a relatively rare complication of TAVR. Little is known about the characteristics of early, intermediate, and late-onset TAVR-IE.
Simrat Kaur, MD, Gursharan Singh Samra, MD, Manpreet Kaur, MD, Nabin K. Shrestha, MD, Steven Gordon, MD, E. Murat Tuzcu, MD, Samir Kapadia, MD, Amar Krishnaswamy, MD, Grant W. Reed, MD, MSc, Rishi Puri, MD, PhD, Lars G. Svensson, MD, PhD, Wael A. Jaber, MD, Brian P. Griffin, MD, Bo Xu, MD   +13 more
doaj   +1 more source

Intermediate Resolution Near-Infrared Spectroscopy of 36 late-M Dwarfs [PDF]

, 2012
We present observations of 36 late-M dwarfs obtained with the KeckII/NIRSPEC in the J-band at a resolution of ∼20,000. We have measured projected rotational velocities, absolute radial velocities, and pseudo-equivalent widths of atomic lines.
Carlos del Burgo Díaz
core   +2 more sources

Mortality patterns and site heterogeneity of severe malaria in African children.

PLoS ONE, 2013
BackgroundIn this study we aimed to assess site heterogeneity of early, intermediate, and late mortality prediction in children with severe Plasmodium falciparum malaria in sub-Saharan Africa.MethodsMedical records of 26,036 children admitted with severe
Eric Kendjo, Tsiri Agbenyega, Kalifa Bojang, Charles R J C Newton, Marielle Bouyou-Akotet, Florian Pedross, Maryvonne Kombila, Raimund Helbok, Peter Gottfried Kremsner   +8 more
doaj   +1 more source

Late-onset Huntington disease with intermediate CAG repeats: true or false? [PDF]

Journal of Neurology, Neurosurgery & Psychiatry, 2010
Huntington disease (HD) is a neurodegenerative disorder associated with an expanded CAG trinucleotide repeat length in the huntingtin gene. 'Intermediate alleles' with 27 to 35 CAG repeats generally do not cause HD but are unstable upon germ-line transmission.
Groen, J.L., de Bie, R.M.A., Foncke, E.M.J., Roos, R.A.C., Leenders, K.L., Tijssen, M.A.J.   +5 more
openaire   +3 more sources

Observing a late folding intermediate of Ubiquitin at atomic resolution by NMR [PDF]

Protein Science, 2016
AbstractThe study of intermediates in the protein folding pathway provides a wealth of information about the energy landscape. The intermediates also frequently initiate pathogenic fibril formations. While observing the intermediates is difficult due to their transient nature, extreme conditions can partially unfold the proteins and provide a glimpse ...
Parag Surana, Ranabir Das
openaire   +2 more sources

Photocatalytic Late-Stage Functionalization of Sulfonamides via Sulfonyl Radical Intermediates

ACS Catalysis, 2022
A plethora of drug molecules and agrochemicals contain the sulfonamide functional group. However, sulfonamides are seldom viewed as synthetically useful functional groups. To confront this limitation, a late-stage functionalization strategy is described, which allows sulfonamides to be converted to pivotal sulfonyl radical intermediates.
Tilby, M, Dewez, D, Pantaine, L, Hall, A, Martinez-Lamenca, C, Willis, M   +5 more
openaire   +4 more sources