Results 41 to 50 of about 166,777 (257)
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Characteristics of rainfall and erosion under natural conditions of land use in semiarid regions
Revista Brasileira de Engenharia Agrícola e Ambiental, 2013 The characteristics of rainfall can provide important information for management and land use may also minimize the water erosion problems. This study was carried out to evaluate soil and water loss in erosion plots with different coverage, and the ...
Cleene A. de Lima +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
A Sense of Space: A GIS Viewshed Analysis of Late Intermediate Period Sites in Moquegua Peru [PDF]
, 2018 This study investigates geospatial relationships among Late Intermediate Period (1000–1400 CE) settlement patterns within the Moquegua River drainage of southern Peru which were first identified in the 1990s by the Moquegua Archaeological Survey (MAS). A
Gay, Brandon
core
Dietary diverstiy in the Atacama desert during the Late intermediate period of northern Chile [PDF]
, 2019 The Pacific Ocean that flanks the hyperarid Atacama Desert of Northern Chile is one of the richest biomass producers around the world. Thus, it is considered a key factor for the subsistence of prehistoric societies (including mixed-economy groups), that
Castro, Victoria +6 more
core +1 more source
Bulletin de l'Institut Français d'Études AndinesThe precordillera of Tacna, between the communities of Sitajara and Tarata, has long had the reputation of being a zone of cohabitation between local, altiplano and coastal populations.
Romuald Housse
doaj +1 more source
Intensity modulated radiotherapy (IMRT) or conformational radiotherapy (3D-CRT) with conventional fractionation for prostate cancer: Is there any clinical difference? [PDF]
International Brazilian Journal of UrologyPurpose: To compare the treatment outcomes of a cohort of prostate cancer patients treated with conventional schedule using IMRT or 3DRT technique.
Gustavo Viani +2 more
doaj +2 more sources
International Journal of Cardiology: Heart & Vasculature, 2020 Background: Early recurrence of atrial tachyarrhythmia (ERAT) during a 90-day blanking period (BP) often occurs after atrial fibrillation (AF) ablation. Left atrial reverse remodeling (LARR), which is the reduction in LA volume (LAV), also occurs during ...
Takafumi Oka +12 more
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Revista Árvore, 2018 Myracrodruon urundeuva, better known in Brazil as “Aroeira”, is an arboreal species highly used for its commercial and pharmacological value. Despite the high commercial value in the timber market, this species lacks studies analyzing the recovery time ...
Sofia Calvo Rodriguez +3 more
doaj +1 more source