Results 51 to 60 of about 166,777 (257)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Family Matters Kinship and Community Composition during the Late Intermediate Period in Andahuaylas, Peru

, 2023
This dissertation uses a multi-method bioarchaeological approach to understand the impact on families and communities during times of socio-political change.
Black, Valda
core   +2 more sources

RELACIONES CERÁMICAS Y SOCIALES ENTRE SAN PEDRO DE ATACAMA Y EL LOA SUPERIOR DURANTE EL PERÍODO INTERMEDIO TARDÍO A TRAVÉS DEL ANÁLISIS DE FLUORESCENCIA DE RAYOS X PORTÁTIL

Estudios Atacameños
Durante el período Intermedio Tardío las comunidades de San Pedro de Atacama y del Loa Superior produjeron tipos cerámicos similares. La cerámica, junto a otros materiales, sugieren una intensificación de una identidad regional compartida durante este ...
Emily Stovel, William Whitehead, Michael Deibel, Mauricio Uribe   +3 more
doaj   +1 more source

Patrón de asentamiento y uso del espacio. Precordillera de Arica, extremo norte de Chile, siglos X-XV

Bulletin de l'Institut Français d'Études Andines, 2005
On the basis of the survey and analysis of a set of about of thirty archaeological sites, an approach is offered to the settlements patterns existing in the premountain range of Arica, northern Chile during centuries X to the XV.
Juan Chacama R.
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Late-time observations of the extraordinary Type II supernova iPTF14hls

, 2019
Aims. We study iPTF14hls, a luminous and extraordinary long-lived Type II supernova, which lately has attracted much attention and disparate interpretation. Methods.
F. Taddia (19107398), C. Barbarino (19119628), X. Wang (770484), D. A. Howell (7684100), S. B. Cenko (7604519), D. Hiramatsu (19119634), I. Arcavi (7679228), J. Sollerman (7603496), L. Tartaglia (19119640), G. Terreran (7662197), S. Valenti (7194734), C. Fransson (19004318), G. Hosseinzadeh (7773488), D. A. Perley (7604513), T. G. Brink (13839646), O. Andersen (19119646), N. Blagorodova (19119631), I. Andreoni (19074509), R. Lunnan (7757465), C. McCully (7813892), J. Burke (7223777), T. de Jaeger (19119637), C. Fremling (19119643), A. V. Filippenko (7605533), A. Gal-Yam (7653392)   +24 more
core   +1 more source

Acerca de complejidad, desigualdad social y el complejo cultural Pica-Tarapacá en los Andes Centro-Sur (1000-1450 DC)

Estudios Atacameños
El propósito principal de este trabajo es revisar los conceptos de complejidad y desigualdad social, intentando comprender arqueológicamente los sistemas que desarrollaron las poblaciones de los Andes Centro-Sur durante el Período Intermedio Tardío, en ...
Mauricio Uribe R
doaj   +1 more source

Tradiciones alfareras, identidad social y el concepto de etnias tardías en Conchucos, Ancash, Perú

Bulletin de l'Institut Français d'Études Andines, 2009
This article explores the issues of social identity, Late Intermediate Period ethnic groups and sociopolitical divisions in relation to the ceramic traditions observed in southern and central Conchucos.
Isabelle Druc
doaj   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Archaeological Investigations at Tambo Colorado (Pisco Valley, South Coast, Peru): The Late Intermediate Period and the Late Horizon occupations

, 2021
This thesis is an archaeological investigation of Tambo Colorado, a major archaeological site in the Pisco Valley (South Coast, Peru). The archaeological site, located on the northern bank of the Pisco river, is known especially for its Inca occupation ...
Moulin, Clea
core