Results 81 to 90 of about 899,905 (333)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Morpho-agronomic performance of vetch species and their accessions grown under nitosol and vertisol conditions in the central highlands of Ethiopia

Agriculture & Food Security, 2018
Background Vetch is one of the promising forage legumes to mitigate the existing critical feed shortage problem in the Ethiopian highlands. The study was conducted to describe the morphological and agronomical traits and to examine the performances of ...
Gezahagn Kebede
doaj   +1 more source

Universal versus economically polarized change in age at first birth : a French–British comparison [PDF]

, 2009
France and the United Kingdom in the 1980s and 1990s represented two contrasting institutional models for the integration of employment and motherhood: The ‘universalistic’ regime type offering subsidized child-care and maternity-leave benefits at all ...
Adsera, Algava, Blank, Boje, Bradshaw, Brewster, Chandola, Chandola, Chiang, Cigno, Desai, Dex, Ekert-Jaffé, Ermisch, Forster, Gauthier, Gauthier, Gauthier, Glover, Gornick, Gornick, Gregory, Grimshaw, Gustafsson, Gustafsson, Hantrais, Hattersley, Hauser, Hoffman, INSEE, Kamerman, Lesthaeghe, McDonald, McLanahan, Meron, Merrigan, Milligan, Pampel, Rendall, Rindfuss, Rosenzweig, Ruhm, Schulze, Sobotka, Stier, Sullivan, Thelot, Toulemon   +47 more
core   +3 more sources

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Magnetic field topology of the unique chemically peculiar star CU Virginis

, 2014
The late-B magnetic chemically peculiar star CU Vir is one of the fastest rotators among the intermediate-mass stars with strong fossil magnetic fields.
C. Neiner, E. Alecian, MiMeS collaboration, O. Kochukhov, T. Lüftinger   +4 more
core   +3 more sources

Late-Time Tails in Gravitational Collapse of a Self-Interacting (Massive) Scalar-Field and Decay of a Self-Interacting Scalar Hair [PDF]

, 1998
We study analytically the initial value problem for a self-interacting (massive) scalar-field on a Reissner-Nordstr\"om spacetime. Following the no-hair theorem we examine the dynamical physical mechanism by which the self-interacting (SI) hair decays ...
C. Gundlach, C. W. Misner, E. Poisson, E. W. Leaver, P. M. Morse, R. H. Price, R. Ruffini, Shahar Hod, Tsvi Piran   +8 more
core   +5 more sources

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Iconographic Similarities Between Permian “Goddess Plaques” (Ural Region, 7-8th Centuries CE) and Horus Cippi (Egypt, 8th Century BCE - 2nd Century CE)

Eikón Imago, 2020
The iconography of the Horus cippus, an amulet popular in Egypt from the late Third Intermediate Period to Roman times (8thcentury BCE - 2nd century CE), is unexpectedly recapitulated in bronze “goddess plaques” of the 7-8th centuries CE made by Permian ...
Lloyd D. Graham
doaj   +1 more source

Apgar score and the risk of cause specific infant mortality: a population based cohort study of 1,029,207 livebirths [PDF]

, 2014
Background<p></p> The Apgar score has been used worldwide as an index of early neonatal condition for more than 60 years. With advances in health-care service provision, neonatal resuscitation, and infant care, its present relevance is ...
Iliodromiti, Stamatina, Mackay, Daniel F., Nelson, Scott M., Pell, Jill P., Smith, Gordon C.S.   +4 more
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source