Results 111 to 120 of about 178,775 (272)

Elucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single‐cell RNA sequencing analysis

open access: yesMolecular Oncology, EarlyView.
Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim   +8 more
wiley   +1 more source

Byzantine Attitudes toward Islam during the Late Middle Ages

open access: yesGreek, Roman, and Byzantine Studies, 2003
[site under construction]
Speros Vryonis Jr
doaj  

ITALIAN MERCHANT ENVIRONMENT AND GENDER IN THE LATE MIDDLE AGES

open access: yesГуманитарные и юридические исследования, 2021
The article discusses the Italian merchant environment and gender stereotypes of behavior in the late Middle Ages. On the basis of the research the author comes to the conclusion that among the ruling elite of Italian cities specific sets developed ...
I. A. Anuprienko
doaj  

The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

open access: yesMolecular Oncology, EarlyView.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair   +17 more
wiley   +1 more source

Was the Cinta Senese Pig Already a Luxury Food in the Late Middle Ages? Ancient DNA and Archaeozoological Evidence from Central Italy. [PDF]

open access: yesGenes (Basel), 2020
Gabbianelli F   +7 more
europepmc   +1 more source

The Shroud of Turin and the Extra Sheds of Warping Threads. How Hard can it be to Set up a 3/1 Chevron Twill, Herringbone on a Warp-weighted Loom?

open access: yesEXARC Journal, 2020
On the 10 May 2020, Mr. Hugh Farey sent me an email. He introduced himself as “a researcher into the weaving of the linen cloth known as the Shroud of Turin”. Then he described the size of the Shroud and how it looked.
Antoinette Merete Olsen
doaj  

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

open access: yesMolecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu   +11 more
wiley   +1 more source

Multiple sclerosis clinical decision support system based on projection to reference datasets

open access: yesAnnals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1863-1873, December 2022., 2022
Abstract Objective Multiple sclerosis (MS) is a multifactorial disease with increasingly complicated management. Our objective is to use on‐demand computational power to address the challenges of dynamically managing MS. Methods A phase 3 clinical trial data (NCT00906399) were used to contextualize the medication efficacy of peg‐interferon beta‐1a vs ...
Chadia Ed‐driouch   +13 more
wiley   +1 more source

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

open access: yesMolecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau   +11 more
wiley   +1 more source

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