Results 111 to 120 of about 3,970,472 (293)
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
Searching for Dubh: Experiments in Black Dyes Pre 15th Century in Ireland and Scotland
EXARC JournalThis paper explores sources of black dyes in Ireland and Scotland prior to 1500, in order to better understand the extent to which they were used and the hues that can be produced.
Ashley Stillwell-Hasan
doaj
Byzantine Attitudes toward Islam during the Late Middle Ages
Greek, Roman, and Byzantine Studies, 2003 [site under construction]
Speros Vryonis Jr
doaj
An Analysis of Contemporary Sources to Uncover the Medieval Identity of the Drink Bochet
EXARC Journal, 2020 When Le Ménagier de Paris (1393), a medieval household manual detailing a woman's proper behavior in marriage and running a household, was newly translated and republished as The Good Wife’s Guide: a Medieval Household Book by the Cornell University ...
Susan Verberg
doaj
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
EXARC Journal, 2017 The International Congress on Medieval Studies is held at Western Michigan University in Kalamazoo each May. Now in its 52nd year, ICMS draws around 3,000 people attending approximately 575 sessions of papers, panel discussions, round tables, workshops ...
Neil Peterson, Karen Davidson
doaj
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
The arms and armour of the municipal war wagon escort in 1521
Fasciculi Archaeologiae Historicae, 2000 ...
Jan Szymczak
doaj