Results 81 to 90 of about 1,913,951 (381)

1. The Absolute Dynastic State

, 1958
One of the most significant developments of the early modern period was the evolution of the national state from its beginnings in the feudal monarchy of the High and Late Middle Ages.
Bloom, Robert L., Crapster, Basil L., Dunkelberger, Harold L., Glatfelter, Charles H., Mara, Richard T., Richardson, Norman E., Schubart, W. Richard   +6 more
core  

Biological and technical complexities in analyzing extracellular vesicle immune interactions in B‐cell malignancies

FEBS Letters, EarlyView.
Daniel Bachurski, Michael Hallek
wiley   +1 more source

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source

Multi‐omic characterization of consensus molecular subtype 1 (CMS1) colorectal cancer with dampened immune response improves precision medicine

Molecular Oncology, EarlyView.
This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti, Manuel Scimeca, Julia Bischof, Jonathan Woodsmith, Massimiliano Agostini, Cristina Fiorani, Yufang Shi, Eleonora Candi, Gerry Melino, Alessandro Mauriello, Giuseppe S. Sica   +10 more
wiley   +1 more source

Lane, pecore e pastori in Puglia fra Tardoantico e Medioevo: novità dai dati archeozoologici [PDF]

, 2012
This paper deals with the bioarchaeological researches on ovine transhumance in Apulia from the Late Antiquity to the Medieval Age, with particular regard to the contribution of the zooarchaeological researches.
Buglione, A., De Venuto, G., Volpe, G.
core  

The Age and Origin of the Gelderse IJssel [PDF]

, 2008
Historic trading cities are located on the Gelderse IJssel and flourished in the late Middle Ages. Little is known about this river in the early Middle Ages and before, and there is considerable debate on the age and origin of the Gelderse IJssel as a ...
Maas, G.J., Makaske, B., Smeerdijk, D.G., van   +2 more
core   +2 more sources

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source

On the origin of Late Antique materials discovered in a Medieval context according to data from the archaeological excavations of the settlement in Petrova Niva locality, “Sboryanovo” archaeological reserve

Приноси към българската археология, 2020
The article analyzes the results of the study of a complicated stratigraphic situation excavated within a single grid square (grid sq. 34/23) of the settlement at Petrova Niva locality, “Sboryanovo” Archaeological Reserve.
Elena Pencheva, Maria Nikolaeva
doaj  

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source

Vergil in the Middle Ages. By DOMENICO COMPARETTI. Trans lated by E. F. L. BENECKE. Pp. xvi, 376. Price, $2.50. New York : Macmillan & Co., I895 [PDF]

, 1896
Dana C. Munro
openalex   +1 more source