Results 141 to 150 of about 4,945,424 (246)

An outer membrane vesicle‐associated two‐track model for enterotoxigenic Bacteroides fragilis oncogenesis

Molecular Oncology, EarlyView.
Enterotoxigenic Bacteroides fragilis is a gut bacterium linked to bowel cancer. We propose that its toxin acts along two routes: at the cell surface, cutting the adhesion protein E‐cadherin and triggering inflammation; and inside the cell, delivered by bacterial vesicles, switching on NOD1 and cancer stem cell programs.
Kangchan Choi, Sang‐Hyeon Yoo, Ki‐Jong Rhee   +2 more
wiley   +1 more source

Historical sources of the High and Late Middle ages

, 2010
Другий том курсу лекцій "Історія середніх віків" присвячений періодам зрілого (його часто називають ще високим)та пізнього Середньовіччя і включає 20 тисяч лекцій.
Коцур В. П., Kotsur V.
core  

Genetic analysis of a representative of the military nobility from the Dal'niy (Vydrin) burial ground of the Chernyakhov culture in the Kursk region. [PDF]

Vavilovskii Zhurnal Genet Selektsii
Rozhdestvenskikh EV, Andreeva TV, Kunizheva SS, Manakhov AD, Gasheva MS, Radyush ОА, Reshetova IK, Dobrovolskaya MV, Rogaev EI.   +8 more
europepmc   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

From Trauma to Innovation: A Comparative History of Limb Amputation and Prosthetics in Humans and Ungulates from Historical and Zooarchaeological Perspectives. [PDF]

Animals (Basel)
Siuta J, Plichta E, Pasicka E.
europepmc   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Postan, Population, and Prices in Late-Medieval England and Flanders [PDF]

This paper re-examines the classic demographic or 'real' model, essentially based on a Malthusian-Ricardian model, that the late Michael Postan (Cambridge) utilized to explain the behaviour of the later-medieval western European economy, and in ...
John Munro
core  

Diagnostic and therapeutic significance of selected antibodies against advanced glycation end-products (anti-AGEs). [PDF]

Mol Biol Rep
Sobczyńska J, Federowicz J, Galińska Z, Ziomek M, Stach W, Bronowicka-Szydełko A, Madziarska K.   +6 more
europepmc   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Adverse early-life conditions and their impact on the marriage market and social mobility: The Poznań birth cohort, 1830-1855. [PDF]

PLoS One
Antosik S, Bengtsson T, Antosik P, Liczbińska G.   +3 more
europepmc   +1 more source