Results 71 to 80 of about 291,220 (232)

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source

Acute HSV-1 Ocular Infection Is Impaired in KLF15 Knockout Mice but Stress-Induced Reactivation from Latency Is Prolonged in Male KLF15 Knockout Mice

Pathogens
Acute human alpha-herpesvirus 1 (HSV-1) infection culminates in a latent infection of neurons in trigeminal ganglia (TG) and the central nervous system.
Kelly S. Harrison, Clinton Jones
doaj   +1 more source

TSTScope Unifies Single‐Cell Multi‐Omics to Identify Functional T Cell States Predictive of Immunotherapy Response

Advanced Science, EarlyView.
TSTScope is an interpretable AI framework that integrates single‐cell transcriptomes with TCR information through curated gene‐program constraints. By linking receptor context to functional T cell states, it reveals response‐associated tumor‐specific T cell programs in lung cancer immunotherapy cohorts and defines an MPR score associated with ...
Shiwei Cao, Jinyu Cheng, Feng‐ao Wang, Chenxin Yi, Jiajun Chen, Keyue Wang, Lulu Liu, Junwei Liu, Yixue Li   +8 more
wiley   +1 more source

Functional Sex Reversal in Adult Gonochoristic Teleosts is Mediated by Ovarian Germline Stem Cell Plasticity and Somatic Cell Transdifferentiation

Advanced Science, EarlyView.
Oocytes play crucial roles in maintaining ovarian fate in adult gonochoristic fish. Targeted oocyte ablation with aromatase inhibition triggers the activation of surviving germline stem cells and the transdifferentiation of somatic cells from granoulosa/theca to Sertoli/Leydig lineages, inducing a complete and functional female‐to‐male sex reversal ...
Yang Yang, Liechao Yu, Wanchang Zhang, Gary Wessel, Ruiyi Chen, Weihua Hu, Dongdong Xu   +6 more
wiley   +1 more source

Endothelial miR‐15a/16‐1 Regulation of SYNE1 Mediates Structural and Functional Recovery after Traumatic Brain Injury

Advanced Science, EarlyView.
Endothelial miR‐15a/16‐1 deletion promotes long‐term recovery after traumatic brain injury by restoring SYNE1 expression. Enhanced endothelial SYNE1 preserves vascular integrity, protects white and gray matter, and improves neurological function. The endothelial miR‐15a/16‐1–SYNE1 axis emerges as a key regulator of neurovascular repair and a potential ...
Shun Li, Na Qiu, Chao Zhou, Andrew Ni, Ping Sun, Jia‐Jun Liu, Xin‐Lei Huang, Tian‐Qing Xiong, Yu‐Chi Zhang, Hai‐Zhou Liu, Xiao‐Tao Xu, Rui Wang, Shi‐Qing Zhang, Yu‐Xin Zhang, Silvia Liu, C. Edward Dixon, Jun Chen, Ke‐Jie Yin   +17 more
wiley   +1 more source

Interleukin-17A directly triggers Epstein-Barr virus lytic reactivation in latency I human B-cell models

Journal of Virology
Epstein-Barr virus (EBV) is a ubiquitous human gammaherpesvirus implicated in inflammatory, malignant, and autoimmune diseases. Although EBV toggles between latent and lytic states, the host cues controlling this switch remain incompletely defined ...
Janardhan Avilala, Hirotomo Dochi, Ramsy Abdelghani, David Becnel, Grace Maresh, Xin Zhang, Li Li, Mark Sides, Gilbert Morris, Hong Liu, Zhen Lin   +10 more
doaj   +1 more source

Mathematical and Statistical Modelling of HIV Latency and Reactivation [PDF]

This thesis explores latency and reactivation of human immunodeficiency virus (HIV) through the use of mathematical and statistical methods. Since HIV was first identified in the 1980s, it has become one of the leading causes of death from an ...
Wu, Yuhuang
core   +1 more source

CpG methylation controls reactivation of HIV from latency. [PDF]

, 2009
DNA methylation of retroviral promoters and enhancers localized in the provirus 5' long terminal repeat (LTR) is considered to be a mechanism of transcriptional suppression that allows retroviruses to evade host immune responses and antiretroviral drugs.
Gondois-Rey, Françoise, Guiguen, Allan, Katerina Trejbalova, Van Lint, Carine, Hejnar, Jiri, Hirsch Ivan, Allan Guiguen, Daniel Olive, Ivan Hirsch, Guiguen Allan, Gondois-Rey Françoise, Halfon Philippe, Blazkova Jana, Blazkova, Jana, Trejbalova Katerina, Verdin, Eric, Philibert Patrick, Patrick Philibert, Carine Van Lint, Halfon, Philippe, Philippe Halfon, Verdin Eric, Jiri Hejnar, Hejnar Jiri, Trejbalova, Katerina, Olive Daniel, Van Lint Carine, Françoise Gondois-Rey, Eric Verdin, Philibert, Patrick, Hirsch, Ivan, Olive, Daniel, Jana Blazkova   +32 more
core   +2 more sources

Loss of LCN2 Function Ameliorates Glucocorticoid‐Induced Muscle Atrophy via Remodeling the Extracellular Matrix

Advanced Science, EarlyView.
Glucocorticoids transcriptionally activate LCN2 expression via GR nuclear translocation. Secreted LCN2 binds MMP9 to degrade skeletal muscle ECM collagen, blocks integrin‐mediated mechanotransduction, bidirectionally disrupts muscle protein homeostasis, and reveals a novel target for steroid‐induced muscle atrophy.
Hongwei Shi, Xiaojing Hao, Yi Yan, Fengyang Li, Yaru Zhang, Zixin Li, Wenjuan Xie, Jiayin Lu, Xiaomao Luo, Yanjun Dong, Haidong Wang, Juan Wang   +11 more
wiley   +1 more source

The nucleic acid binding protein SFPQ represses EBV lytic reactivation by promoting histone H1 expression

Nature Communications
Epstein-Barr virus (EBV) uses a biphasic lifecycle of latency and lytic reactivation to infect >95% of adults worldwide. Despite its central role in EBV persistence and oncogenesis, much remains unknown about how EBV latency is maintained.
Laura A. Murray-Nerger, Clarisel Lozano, Eric M. Burton, Yifei Liao, Nathan A. Ungerleider, Rui Guo, Benjamin E. Gewurz   +6 more
doaj   +1 more source