Results 211 to 220 of about 5,459,614 (334)

Gut Microbiota‐Derived Anandamide Mediates the Therapeutic Effects of Urolithin A on Alcohol‐Induced Cognitive and Social Dysfunction via CB1R‐DRD2‐RAP1 Signaling Axis

Advanced Science, EarlyView.
This study reveals that Urolithin A (UA) counteracts alcohol‐induced cognitive and social dysfunction (AICSD) via a gut microbiome‐dependent mechanism. UA‐enriched Bacteroids sartorii and Parabacteroids distasonis elevate anandamide (AEA), which activates the CB1R‐DRD2‐Rap1 signaling cascade to drive synaptic repair and reduce neuroinflammation ...
Hongbo Zhang, Zibin Li, Yao Xiao, Ji Bian, Caian He, Chao Liu, Lan Gong, Lin Han, Zhigang Liu, Min Wang   +9 more
wiley   +1 more source

Transitions in and out of Loneliness During the COVID-19 Pandemic: A Latent Class Analysis of Older Adults in England. [PDF]

Sociol Health Illn
Joshi M, Weber D, Goujon A.
europepmc   +1 more source

Machine‐Learning Decomposition Identifies a Big Two Structure in Human Personality with Distinct Neurocognitive Profiles

Advanced Science, EarlyView.
Using machine learning on a mega‐scale global dataset (n = 1,336,840) reveals a robust personality trait architecture beyond the Big Five. A Big Two model, broadly capturing social engagement and internal mentation, defines a geometric space that links personality to neurocognitive profiles.
Kaixiang Zhuang, Ji Chen, Jinfeng Han, Wei Cheng, Jiang Qiu, Jianfeng Feng, Simon Eickhoff, Deniz Vatansever   +7 more
wiley   +1 more source

Identifying Cardio-Metabolic Subtypes of Prediabetes Using Latent Class Analysis. [PDF]

Med Sci (Basel)
Nuskabayeva G, Saruarov Y, Sadykova K, Zhunissova M, Nurdinov N, Babayeva K, Li M, Zhailkhan A, Kabibulatova A, Kabibulatova A, Sarria-Santamera A.   +10 more
europepmc   +1 more source

The Osteoblastic Microenvironment Determines the Fate of Breast Cancer Cells Disseminated in the Bone Marrow

Advanced Science, EarlyView.
This study revealed how the osteoblastic microenvironment determines the fate of cancer cells disseminated in bone, with a focus on whether they colonize, reside in quiescence, or reactivate from dormancy. Targeting integrin signaling may offer promising strategies for preventing quiescent cancer cells reactivation and bone colonization.
Hong‐Li Wang, Rui Zhang, Xiao‐Min Yue, Jie Zhou, Yu‐Fan Huang, Rong Meng, Yu‐Li Wang, Xiao‐Qing Li   +7 more
wiley   +1 more source

Rural-Urban Comparison of Health Risk Behaviors and Health Outcomes Among Chinese Older Adults: A Latent Class Analysis. [PDF]

J Cross Cult Gerontol
Xu C, Lee YH, Shelley M, Lu P.
europepmc   +1 more source

Divergent Responses of Bacterial Communities to Permafrost Degradation and Their Associations With Carbon Across Vertical Profiles

Advanced Science, EarlyView.
Bacterial α‐diversity decreases, but stochasticity and community stability increase across the 15 m‐depth vertical profiles and along the degraded gradient within the active layer. The abundance and interaction of core taxa mainly control community stability in the active and permafrost layers, respectively.
Shengyun Chen, Yuzheng Gu, Ali Bahadur, Enyan Liu, Tonghua Wu, Xiaofan Zhu, Yuanqiang Zou, Hewei Liang, Peijie Wei, Linwei Wu, Qingbai Wu, Peizhi Yang, Hongyan Yu, Yunfeng Yang   +13 more
wiley   +1 more source

Latent class analysis of oral symptoms in stroke patients and exploration of associated. [PDF]

BMC Oral Health
Zhu H, Zhang F, Li S, Wen Q, Wang X, Xian L, Li J.   +6 more
europepmc   +1 more source

Les classes latentes

, 2005
Les modèles à variables latentes ont été introduits dans les sciences humaines dès le début du siècle avec lanalyse factorielle de Spearman puis de Thurstone. Ils postulent lexistence de variables inobservables directement (appelées facteurs ou variables latentes)mais dont on peut mesurer ou observer des conséquences, ou effets.Lhypothèse fondamentale ...
openaire   +1 more source