Results 51 to 60 of about 140,759 (263)

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

Cardiometabolic multimorbidity in Mexican adults: a cross-sectional analysis of a national survey

Frontiers in Medicine
BackgroundCardiometabolic multimorbidity is a rising phenomenon that has been barely explored in middle-income countries such as Mexico.ObjectiveThis study aimed to estimate the prevalence, associated factors, and patterns of cardiometabolic ...
Marcela Agudelo-Botero, Claudio A. Dávila-Cervantes, Liliana Giraldo-Rodríguez   +2 more
doaj   +1 more source

Analyses des classes et des transitions latentes : des outils pour documenter le parcours de développement des compétences. [PDF]

Tutorials in Quantitative Methods for Psychology, 2015
Our proposal is that the process of validating the construct of a competency inferred from an observation grid raises a multivariate and multi-dimensional latent classification problem.
Léon Harvey
doaj  

Added Prognostic Value of EEG Reactivity in Comatose Patients Following Cardiac Arrest

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives To evaluate the added prognostic value of EEG reactivity for favorable outcome compared with background analysis during and after targeted temperature management (TTM). Methods Prospective observational cohort study of comatose post–cardiac arrest patients admitted to a single academic center between 2017 and 2022, all undergoing ...
Sarah Caroyer, Marie Obrecht, Charlotte de Maeseneire, Charlotte Damien, Chantal Depondt, Lorenzo Ferlini, Estelle Rikir, Filippo Annoni, Fabio Silvio Taccone, Nicolas Mavroudakis, Benjamin Legros, Nicolas Gaspard   +11 more
wiley   +1 more source

Monarch Butterfly Conservation Through the Social Lens: Eliciting Public Preferences for Management Strategies Across Transboundary Nations

Frontiers in Ecology and Evolution, 2019
The monarch butterfly (Danaus plexippus), an iconic species that migrates annually across North America, has steeply declined in numbers over the past decade.
Rodrigo Solis-Sosa, Christina A. D. Semeniuk, Sergio Fernandez-Lozada, Kornelia Dabrowska, Sean Cox, Wolfgang Haider   +5 more
doaj   +1 more source

White Matter Hyperintensity Burden and Short‐Interval Change Associated With Sleep Apnoea in the UK Biobank

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Purpose White matter hyperintensities (WMH) are a core neuroimaging marker of cerebral small vessel disease (CSVD). Sleep apnoea (SA) is a recognized vascular risk factor, but its associations with regional WMH burden, short‐interval WMH change and cognitive performance in population‐based cohorts remain incompletely defined. We
Peng Cheng, Diego Z. Carvalho, Shahid Karim, Anwar Chahal, Virend K. Somers   +4 more
wiley   +1 more source

Post-material values and brain drain: how value transformation shapes the migration mindset among highly educated South Asians?

Frontiers in Sociology
While economic reasons are predominantly considered as drivers of brain drain in the existing literature, the present study demonstrates that migration decisions are substantially shaped by structural misalignments between individuals’ value orientations
Samitha Udayanga
doaj   +1 more source

Movement Disorders in Aicardi–Goutières Syndrome and Response to Immunomodulation

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT This study characterizes movement disorders and treatment responses in seven children with Aicardi–Goutières syndrome (AGS). We retrospectively evaluated motor phenotypes, neuroimaging, and interferon signatures in patients treated with baricitinib or anifrolumab. Spasticity affected all patients, while dystonia was present in 4/7.
Enrique Gonzalez Saez‐Diez, Monica Ferrer Socorro, Kathryn Yang, Nicole Battaglia, Zainab Zaman, Mariko Bennett, Adeline Vanderver, Pui Y. Lee, Lauren A. Henderson, Milena M. Andzelm, Darius Ebrahimi‐Fakhari   +10 more
wiley   +1 more source

Comparative Effectiveness and Safety of Inebilizumab Versus Rituximab in AQP4‐IgG‐Positive NMOSD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rituximab (anti‐CD20, RTX) and inebilizumab (anti‐CD19, INE) represent B‐cell‐depleting therapies used for aquaporin‐4 antibody‐positive (AQP4‐IgG+) neuromyelitis optica spectrum disorder (NMOSD); however, direct comparative evidence remains limited.
Jie Lin, Binbin Xue, Dewei Xie, Jia Li, Juyuan Pan, Lanbing Zhu, Qiaowen Tong, Jing Lin, Ruofan Zhu, Xu Zhang, Junhui Xia, Xiang Li   +11 more
wiley   +1 more source

Uncovering eHealth Engagement Patterns Through Latent Class Analysis and SHAP: A Data Mining Perspective on Telehealth Access

Information
Understanding how patients engage with digital health technologies is critical for improving the reach and equity of telehealth services. While prior research has largely focused on demographic predictors of telehealth use, this study applies a hybrid ...
Ning Yang, Xin Yang
doaj   +1 more source