Results 41 to 50 of about 144,767 (294)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Latent class analysis of co-morbidity in the Adult Psychiatric Morbidity Survey in England 2007 : implications for DSM-5 and ICD-11 [PDF]

, 2011
Background. Psychiatric co-morbidity is complex and ubiquitous. Our aim was to describe the extent, nature and patterning of psychiatric co-morbidity within a representative sample of the adult population of England, using latent class analysis ...
Exeter, D., O. McBride, D. Exeter, McManus, Sally, McBride, O., Hussey, D., S. McManus, D. Hussey, Weich, Scott, Brugha, T. S. (Traolach S.), S. Weich, T. Brugha   +11 more
core   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Unmodeled DIF in latent class analysis: Consequences for class enumeration

Methods in Psychology
This paper builds upon previous research to investigate the effects of misspecified covariate relations in latent class analysis (LCA) using a Monte Carlo simulation.
Dina A.N. Arch, Karen Nylund-Gibson
doaj   +1 more source

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

FEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source

Latent class analysis as a typology identification technique

INFAD, 2019
In Psychology, it is common to find situations in which some kind of classification of people in subgroups or classes is needed. There are multivariate analysis techniques such as Hierarchical Cluster Analysis (HCA) that are  commonly used for this ...
Daniel Ondé Pérez, Jesús María Alvarado Izquierdo   +1 more
doaj   +1 more source

A data‐driven examination of apathy and depressive symptoms in dementia with independent replication

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2023
Apathy is one of the most common neuropsychiatric symptoms (NPS) and is associated with poor clinical outcomes. Research that helps define the apathy phenotype is urgently needed, particularly for clinical and biomarker studies.
Miguel Vasconcelos Da Silva, Gerardo Javier Melendez‐Torres, Zahinoor Ismail, Ingelin Testad, Clive Ballard, Byron Creese, for the Alzheimer's Disease Neuroimaging Initiative   +6 more
doaj   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

poLCA: An R Package for Polytomous Variable Latent Class Analysis

Journal of Statistical Software, 2011
poLCA is a software package for the estimation of latent class and latent class regression models for polytomous outcome variables, implemented in the R statistical computing environment. Both models can be called using a single simple command line.
Drew A. Linzer, Jeffrey B. Lewis
doaj  

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source