Results 31 to 40 of about 127,444 (251)
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Preventive Medicine Reports, 2021 Unprecedented global efforts in vaccine development have resulted in effective vaccines for COVID-19. The pandemic response in the US has been highly politicized, resulting in significant opposition to public health efforts, including vaccines.
Kristin E. Schneider +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Unmodeled DIF in latent class analysis: Consequences for class enumeration
Methods in PsychologyThis paper builds upon previous research to investigate the effects of misspecified covariate relations in latent class analysis (LCA) using a Monte Carlo simulation.
Dina A.N. Arch, Karen Nylund-Gibson
doaj +1 more source
A data‐driven examination of apathy and depressive symptoms in dementia with independent replication
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2023 Apathy is one of the most common neuropsychiatric symptoms (NPS) and is associated with poor clinical outcomes. Research that helps define the apathy phenotype is urgently needed, particularly for clinical and biomarker studies.
Miguel Vasconcelos Da Silva +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant +11 more
wiley +1 more source
poLCA: An R Package for Polytomous Variable Latent Class Analysis
Journal of Statistical Software, 2011 poLCA is a software package for the estimation of latent class and latent class regression models for polytomous outcome variables, implemented in the R statistical computing environment. Both models can be called using a single simple command line.
Drew A. Linzer, Jeffrey B. Lewis
doaj
Latent class analysis as a typology identification technique
INFAD, 2019 In Psychology, it is common to find situations in which some kind of classification of people in subgroups or classes is needed. There are multivariate analysis techniques such as Hierarchical Cluster Analysis (HCA) that are commonly used for this ...
Daniel Ondé Pérez +1 more
doaj +1 more source
FEBS Open Bio, EarlyView.Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin +3 more
wiley +1 more source