Epstein-Barr Virus Latent Membrane Protein-1 Expression in Nasopharyngeal Carcinoma [PDF]
JCO Global Oncology, 2021 PURPOSENasopharyngeal carcinoma (NPC), a malignant neoplasm of the epithelium covering the nasopharynx, is a rare disease in most parts of the world.
Valerie E. Salano +4 more
doaj +5 more sources
In Silico Modeling and Characterization of Epstein–Barr Virus Latent Membrane Protein 1 Protein [PDF]
ACS OmegaLatent membrane protein 1 (LMP1) plays a crucial role in Epstein-Barr virus (EBV)'s ability to establish latency and is involved in developing and progressing EBV-associated cancers. Additionally, EBV-infected cells affect the immune responses, making it challenging for the immune system to eliminate them.
Dayang-Sharyati D. A. Salam +5 more
doaj +4 more sources
Latent Membrane Protein 1 Promotes Tumorigenesis Through Upregulation of PGC1β Signaling Pathway. [PDF]
Stem Cell Rev Rep, 2021 AbstractNatural killer/T-cell lymphoma (NKTCL) is an aggressive Epstein-Barr virus (EBV)-associated non-Hodgkin lymphoma with poor prognosis. In this study, we aimed to investigate the potential mechanism of latent membrane protein 1 (LMP1)-mediated tumorigenesis and provide a novel therapeutic strategy for targeting the EBV DNA genome.
Feng J +6 more
europepmc +4 more sources
Computational identification of PTPRJ peptide targeting the Epstein Barr virus latent membrane protein 1 [PDF]
Scientific ReportsThe treatment of Epstein-Barr virus (EBV)-associated malignancies is increasingly recognizing the necessity of personalized medicine strategies to enhance therapeutic outcomes.
Dayang-Sharyati D. A. Salam +2 more
doaj +2 more sources
Epstein-Barr virus latent membrane protein 1 subverts IMPDH pathways to drive B-cell oncometabolism. [PDF]
PLoS PathogensEpstein-Barr virus (EBV) is associated with multiple types of cancers, many of which express the viral oncoprotein Latent Membrane Protein 1 (LMP1). LMP1 contributes to both epithelial and B-cell transformation.
Eric M Burton +6 more
doaj +2 more sources
Modification of Cɛ mRNA Expression by EBV-Encoded Latent Membrane Protein 1 [PDF]
Mediators of Inflammation, 2006 To evaluate the effect of expression of latent membrane protein (LMP) 1 encoded by Epstein-Barr virus (EBV) on Cɛ mRNA expression, mRNA levels were examined by RT-PCR or Northern blot analysis upon transient transfection of LMP1 in the splenocytes ...
Kazuhiko Hanashiro +5 more
doaj +3 more sources
A Systematic Review of Epstein–Barr Virus Latent Membrane Protein 1 (LMP1) Gene Variants in Nasopharyngeal Carcinoma [PDF]
Pathogens, 2021 Nasopharyngeal carcinoma (NPC) is an aggressive tumor with a complex etiology. Although Epstein–Barr virus (EBV) infection is known environmental factor for NPC development, the degree to which EBV naturally infects nasopharyngeal epithelium and the ...
Ana Banko +3 more
doaj +2 more sources
Overexpression of Epstein-Barr virus-encoded latent membrane protein-1 (LMP-1) in oral squamous cell carcinoma [PDF]
BMC Oral Health, 2019 Background As oral cavity is the main location of Epstein-Barr virus (EBV) latency and shedding, and as EBV-encoded latent membrane protein-1 (LMP-1) has a crucial role in cell transformation, association between EBV infection, LMP-1 expression and oral ...
Rifat Rahman +3 more
doaj +2 more sources
Epstein-Barr Functional Mimicry: Pathogenicity of Oncogenic Latent Membrane Protein-1 in Systemic Lupus Erythematosus and Autoimmunity [PDF]
Frontiers in Immunology, 2021 Systemic lupus erythematosus (SLE) and other autoimmune diseases are propelled by immune dysregulation and pathogenic, disease-specific autoantibodies.
Melissa E. Munroe +9 more
doaj +2 more sources
Latent Membrane Protein 1 of Epstein–Barr Virus Promotes RIG-I Degradation Mediated by Proteasome Pathway [PDF]
Frontiers in Immunology, 2018 RIG-I signaling is critical to host innate immune response against RNA virus infection, and also can be activated against many kinds of cancer. Oncogene LMP1 of Epstein–Barr virus (EBV) contributes to various tumors progress.
Chongfeng Xu +3 more
doaj +2 more sources