Direct Immunosuppressive Effects of EBV-Encoded Latent Membrane Protein 1 [PDF]
The Journal of Immunology, 2000 Abstract In neoplastic cells of EBV-positive lymphoid malignancies latent membrane protein (LMP1) is expressed. Because no adequate cellular immune response can be detected against LMP1, we investigated whether LMP1 had a direct effect on T lymphocyte activation.
Dukers, D F +7 more
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N-acetylcysteine (NAC) ameliorates Epstein-Barr virus latent membrane protein 1 induced chronic inflammation. [PDF]
PLoS ONE, 2017 Chronic inflammation results when the immune system responds to trauma, injury or infection and the response is not resolved. It can lead to tissue damage and dysfunction and in some cases predispose to cancer. Some viruses (including Epstein-Barr virus (
Xiao Gao +5 more
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Toll-like receptor 7 stimulates the expression of Epstein-Barr virus latent membrane protein 1. [PDF]
PLoS ONE, 2012 Epstein-Barr virus (EBV) is a ubiquitous human herpesvirus. Toll-like receptor 7 (TLR7) is involved in host innate immunity against pathogens, and its aberrant activation is linked to the development of systemic lupus erythematosus (SLE, also called ...
Robert M Valente +9 more
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Epstein-Barr Virus Regulates STAT1 through Latent Membrane Protein 1 [PDF]
Journal of Virology, 2003 ABSTRACT This study shows a mechanism for the increase of signal transducer and activator of transcription 1 (STAT1) in Epstein-Barr virus-immortalized cells. Latent membrane protein 1 (LMP-1) expression was sufficient to induce STAT1 expression, DNA binding, and transcriptional activity. LMP-1-expressing cells can induce an increase in STAT1
Ciarán, Richardson +3 more
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Tumor Biology, 2020 Epstein–Barr virus is an etiologic agent of several malignancies. In this study, we explored the association of Epstein–Barr virus–encoded RNA1 and Epstein–Barr virus latent membrane protein 1 co-expression with osteosarcoma.
Keykhosro Mardanpour +4 more
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EBV latent membrane protein 1 activates Akt, NFkappaB, and Stat3 in B cell lymphomas. [PDF]
PLoS Pathogens, 2007 Latent membrane protein 1 (LMP1) is the major oncoprotein of Epstein-Barr virus (EBV). In transgenic mice, LMP1 promotes increased lymphoma development by 12 mo of age.
Kathy H Y Shair +5 more
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Regulation of Latent Membrane Protein 1 Signaling through Interaction with Cytoskeletal Proteins [PDF]
Journal of Virology, 2015 ABSTRACT Latent membrane protein 1 (LMP1) of Epstein-Barr virus (EBV) induces constitutive signaling in EBV-infected cells to ensure the survival of the latently infected cells. LMP1 is localized to lipid raft domains to induce signaling. In the present study, a genome-wide screen based on bimolecular fluorescence complementation (BiFC) was ...
Kirsten, Holthusen +2 more
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Poly(ADP-ribose) polymerase 1 is necessary for coactivating hypoxia-inducible factor-1-dependent gene expression by Epstein-Barr virus latent membrane protein 1. [PDF]
PLoS Pathogens, 2018 Latent membrane protein 1 (LMP1) is the major transforming protein of Epstein-Barr virus (EBV) and is critical for EBV-induced B-cell transformation in vitro. Poly(ADP-ribose) polymerase 1 (PARP1) regulates accessibility of chromatin, alters functions of
Michael Hulse +5 more
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Prognostic significance of EBV latent membrane protein 1 expression in lymphomas: evidence from 15 studies. [PDF]
PLoS ONE, 2013 Epstein-Barr virus (EBV) infection has been associated with lymphoma development. EBV latent membrane protein 1 (LMP1) is essential for EBV-mediated transformation and progression of different human cells, including lymphocytes.
Yuan Mao +9 more
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Virology, 2001 The frequent coexpression of the EBV-encoded latent membrane proteins LMP1 and LMP2A/B in virus-associated tumors suggests that these two proteins may cooperate in the transformation process. While LMP2A is unable to directly activate the NF-kappaB and AP-1 pathways, we found that coexpression of LMP2A with LMP1 resulted in a significant enhancement of
Dawson, Christopher W. +4 more
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