EBV Latent Membrane Protein 1 Is a Negative Regulator of TLR9 [PDF]
The Journal of Immunology, 2010 Abstract EBV infects most of the human population and is associated with a number of human diseases including cancers. Moreover, evasion of the immune system and chronic infection is an essential step for EBV-associated diseases. In this paper, we show that EBV can alter the regulation and expression of TLRs, the key effector molecules ...
Ikbal, Fathallah +9 more
openaire +2 more sources
Egr‐1, a new downstream molecule of Epstein‐Barr virus latent membrane protein 1 [PDF]
FEBS Letters, 2007 To investigate the effect of Epstein‐Barr virus (EBV) latent membrane protein 1 (LMP1) on human cancer cells, we sought to identify and analyze potential target genes that were differentially expressed in the presence and absence of LMP1. Our cDNA microarray analysis revealed that expression of early growth response gene‐1 (Egr‐1) was increased by LMP1
Kim, Joo Hyun +5 more
openaire +2 more sources
Identification and prevalence of CD8+ T‐cell responses directed against Epstein‐Barr virus‐encoded latent membrane protein 1 and latent membrane protein 2 [PDF]
International Journal of Cancer, 2002 AbstractEpstein‐Barr virus (EBV) is associated with several human malignancies that each show different viral gene expression profiles. In malignancies such as Hodgkin's disease and nasopharyngeal carcinoma only Epstein‐Barr nuclear antigen 1 (EBNA1) and varying levels of latent membrane proteins 1 and 2 (LMP1 and ‐2) are expressed.
Meij, Pauline +6 more
openaire +4 more sources
EBV based cancer prevention and therapy in nasopharyngeal carcinoma
npj Precision Oncology, 2017 Epstein–Barr virus is an important cancer causing virus. Nasopharyngeal carcinoma is an infection-related cancer strongly driven by Epstein–Barr virus.
Ya Cao
doaj +1 more source
Epstein-Barr Virus Latent Membrane Protein 1: Structure and Functions
Journal of Biomedical Science, 2003 The Epstein-Barr virus latent membrane protein (LMP) 1 is a versatile protein that has profound effects on target cells through its effect on constitutive cellular proteins, e.g. TRAFs, TRADD, RIP, JAK3, BRAM1, and p85. LMP1 can stimulate or inhibit signaling pathways, resulting in transformation of rodent fibroblast cell lines, blockade of ...
Hsin-Pai, Li, Yu-Sun, Chang
openaire +2 more sources
NF-κB and IRF7 Pathway Activation by Epstein-Barr Virus Latent Membrane Protein 1
Viruses, 2013 The principal Epstein-Barr virus (EBV) oncoprotein, Latent Membrane Protein 1 (LMP1), is expressed in most EBV-associated human malignancies. LMP1 mimics CD40 receptor signaling to provide infected cells with constitutive NF-κB, MAP kinase, IRF7, and PI3
Benjamin E. Gewurz +2 more
doaj +1 more source
Epstein-Barr Virus Latent Membrane Protein 1 Induces Synthesis of Hypoxia-Inducible Factor 1α [PDF]
Molecular and Cellular Biology, 2004 Hypoxia-inducible factor 1 (HIF-1) is a heterodimeric basic helix-loop-helix transcription factor composed of HIF-1α and HIF-1β that is the central regulator of responses to hypoxia. The specific binding of HIF-1 to the hypoxia-responsive element (HRE) induces the transcription of genes that respond to hypoxic conditions, including vascular endothelial
Naohiro, Wakisaka +5 more
openaire +2 more sources
Id1 interacts and stabilizes the Epstein-Barr virus latent membrane protein 1 (LMP1) in nasopharyngeal epithelial cells. [PDF]
PLoS ONE, 2011 The EBV-encoded latent membrane protein 1 (LMP1) functions as a constitutive active form of tumor necrosis factor receptor (TNFR) and activates multiple downstream signaling pathways similar to CD40 signaling in a ligand-independent manner.
Pok Man Hau +4 more
doaj +1 more source
RECK is a target of Epstein–Barr virus latent membrane protein 1 [PDF]
Oncogene, 2003 Epstein-Barr virus (EBV) latent membrane protein 1 (LMP1) has been suggested to be involved in tumor metastasis. However, the molecular mechanism of LMP1-induced metastasis is largely unknown. In this study, we investigated the effect of LMP1 on the expression of RECK, a metastasis suppressor gene, in an EBV-negative nasopharyngeal carcinoma (NPC) cell
Li-Teh, Liu +3 more
openaire +2 more sources
Latent membrane protein 1 is dispensable for Epstein-Barr virus replication in human embryonic kidney 293 cells. [PDF]
PLoS ONE, 2011 Epstein Barr Virus (EBV) replicates in oral epithelial cells and gains entry to B-lymphocytes. In B-lymphocytes, EBV expresses a restricted subset of genes, the Latency III program, which converts B-lymphocytes to proliferating lymphoblasts.
Vicki Geiser +2 more
doaj +1 more source