Results 191 to 200 of about 409,589 (330)

Mechanostimulatory Cues Determine Intestinal Fibroblast Fate and Profibrotic Remodeling in a Physiodynamic Human Gut‐on‐a‐Chip

Advanced Science, EarlyView.
A healthy gut barrier shields underlying fibroblasts from luminal shear forces, illustrating that “good fences make good neighbors.” Barrier damage exposes fibroblasts to shear stress, inducing cell death and the emergence of stress‐adapted, profibrotic fibroblasts. Sustained shear exposure promotes the formation of stiff aggregates of mechanoadapative
Soyoun Min, Nam Than, Yong Cheol Shin, Elif G. Ertugral, Chandrasekhar R. Kothapalli, Olumuyiwa Awoniyi, Hyun Jung Kim   +6 more
wiley   +1 more source

Influenza vaccine Hesitancy in older adults in China: A latent profile analysis. [PDF]

Hum Vaccin Immunother
Chen X, Xia S, Zhu Z, Hui Z, Wu J, Sun C, Zhou C, Ceng L.   +7 more
europepmc   +1 more source

High‐Fidelity Synthetic Data Replicates Clinical Prediction Performance in a Million‐Patient Diabetes Cohort

Advanced Science, EarlyView.
This study generates high‐fidelity synthetic longitudinal records for a million‐patient diabetes cohort, successfully replicating clinical predictive performance. However, deeper analysis reveals algorithmic biases and trajectory inconsistencies that escape standard quality metrics. These findings challenge current validation norms, demonstrating why a
Francisco Ortuño, Víctor M. de la Oliva Roque, Javier‐Ignacio Ramirez‐Lopez, David P. Kreil, Joaquín Dopazo, Carlos Loucera   +5 more
wiley   +1 more source

Academic burnout profiles and their correlates: a latent profile analysis of Chinese university students. [PDF]

Front Psychol
Li Y, Li Y, Ye X, Yan S.
europepmc   +1 more source

Latent profile and cluster analysis of infant temperament: Comparisons across person-centered approaches.

, 2017
Maria A. Gartstein, Amanda Prokasky, Martha Ann Bell, Susan D. Calkins, David J. Bridgett, Julia M. Braungart‐Rieker, Esther M. Leerkes, Carol L. Cheatham, Rina D. Eiden, Krystal D. Mize, Nancy Aaron Jones, Gina C. Mireault, Erich Seamon   +12 more
openalex   +1 more source

A Tac1‐Expressing Brainstem Pathway Underlies the Pathogenesis of Trigeminal Neuralgia

Advanced Science, EarlyView.
A critical TG‐Sp5CTac1‐PBNTac1 pathway drives trigeminal neuropathic pain (TNP). Tac1‐expressing parabrachial nucleus (PBNTac1) neurons exhibit heightened responses to innocuous stimuli in TNP, and chemogenetic inhibition of these neurons effectively prevents TNP development.
Liting Sun, Jia‐Jia Wang, Xiang‐Yu Li, Xin‐Yi Lin, Juan Li, Qiu‐Tong Yu, Zi‐Han Wang, Xue‐Ping Gao, Lei Jin, Wei‐Ke Li, Tian‐Lin Cheng, Juan Deng   +11 more
wiley   +1 more source

Latent profile analysis of fertility intention among women of reproductive age. [PDF]

Front Reprod Health
Chen M, Ma S, Liu X, Wang L, Zheng Y, Lai J, Li J, Qi Y.   +7 more
europepmc   +1 more source

Targeting the PDK1/c‐Myc/SOX10 Signaling in Oligodendrocytes Alleviates Neuropathic Pain

Advanced Science, EarlyView.
This work reveals that oligodendrocyte homeostasis, mediated by PDK1, is a critical determinant of neuropathic pain (NPP) pathogenesis. Disruption of PDK1 in oligodendrocytes impairs SOX10‐dependent myelination programs through c‐Myc accumulation, leading to disrupted myelination and the pathophysiology of NPP.
Pingping Qiao, Lifang Guo, Guochao Yang, Chaoli Huang, He Wang, Jian‐Jun Yang, Guiquan Chen, Yimin Hu   +7 more
wiley   +1 more source

Latent profile analysis and associated factors of kinesophobia in patients with hip fractures. [PDF]

BMC Psychol
Xinxia W, Dalin K, Juan J, Mingzhe D, Lixia Z, Weiling F, Wei J.   +6 more
europepmc   +1 more source

Gaining Insights into Aggressive Behaviour in Autism Spectrum Disorder Using Latent Profile Analysis [PDF]

, 2019
Matthew O. Sullivan, Louise Gallagher, Elizabeth A. Heron   +2 more
openalex   +1 more source