Results 201 to 210 of about 99,241 (260)

A Skull Bone Marrow‐to‐Brain Axis Links Osteoblastic Activity to Myeloid Cell Trafficking, Cerebral Blood Flow, and Cognition in Alzheimer's Progression

Advanced Science, EarlyView.
This study reveals that Alzheimer's disease–linked APP expression in bone‐forming cells drives skull bone marrow remodeling and alters its vascular connections to the brain. These changes disrupt immune cell trafficking, cerebral blood flow, and cognition. Targeting bone marrow macrophages restores brain function, highlighting a previously unrecognized
Lei Xiong, Dong Sun, Hao‐Han Guo, Daehoon Lee, Zhipeng Liu, Lin Mei, Wen‐Cheng Xiong   +6 more
wiley   +1 more source

Identifying subgroups of individuals undergoing metabolic bariatric surgery based on behavioral and psychosocial factors: A latent profile analysis. [PDF]

PLoS One
Kuipers EAM, Timmerman JG, van Det MJ, Vermeer M, Vollenbroek-Hutten MMR.   +4 more
europepmc   +1 more source

Diffusion‐Based Generative Model With Scaffold‐Hopping Strategy Yields Highly Potent Bioactive Molecules

Advanced Science, EarlyView.
SMarT‐Diff introduces a multi‐objective generative paradigm that integrates scaffold hopping with structure‐aware scoring to enable controlled exploration beyond the training distribution. The framework consistently balances drug‐likeness, synthesizes accessibility and bioactivity, yielding chemically diverse candidates with enhanced properties.
Yuwei Yang, Xiaoqing Gong, Shukai Gu, Jing Li, Bo Liu, Yanan Tian, Qianqian Zhang, Xiaojun Yao, Huanxiang Liu   +8 more
wiley   +1 more source

Chemotherapy-related symptoms in colorectal cancer patients: A latent profile analysis. [PDF]

BMC Cancer
Xia W, Luo Z, Shan S, Chen J, Guo D, Tian L.   +5 more
europepmc   +1 more source

Inhibitory Decay and Supercritical Brain Dynamics During Sleep Deprivation

Advanced Science, EarlyView.
Sleep deprivation progressively shifts human brain dynamics from near‐critical toward supercritical states, as revealed by neuronal avalanche analysis of resting‐state fMRI. These changes track subjective sleep pressure rather than vigilance lapses and show marked network heterogeneity. A circuit model suggests that reduced inhibitory efficacy provides
Dai Zhang, Liqin Zhou, Rong Wang, Yuehua Han, Zhentao Zuo, Yanghua Tian, Ke Zhou   +6 more
wiley   +1 more source

Influenza vaccine Hesitancy in older adults in China: A latent profile analysis. [PDF]

Hum Vaccin Immunother
Chen X, Xia S, Zhu Z, Hui Z, Wu J, Sun C, Zhou C, Ceng L.   +7 more
europepmc   +1 more source

Bilateral SERS‐Microneedle Patch for Co‐Diagnosis of Diabetes Mellitus and Tuberculosis Comorbidity

Advanced Science, EarlyView.
Our study introduced a U@mP@Au‐mediated bilateral SERS‐microneedle patch for analyzing glucose levels from ISF and sensitively detecting TB biomarkers from sputum, respectively. This integrated dual‐analyte detecting platform can be used for co‐diagnosis of diabetes mellitus (DM) and tuberculosis (TB) comorbidity, which was demonstrated in ex vivo ...
Xueqin Huang, Lingzhi Chen, Jing Xu, Jiaqi Yu, Shanze Chen, Huaihong Cai, Yanguang Cong, Pinghua Sun, Jiang Pi, Lang Rao, Jierong Chen, Junxia Zheng, Haibo Zhou   +12 more
wiley   +1 more source

Patterns and predictors of cognitive function and post-traumatic growth in cancer patients: a latent profile analysis. [PDF]

Front Psychiatry
Zhang L, Huang R, Cao M, Fang J, Lu D.
europepmc   +1 more source

Academic burnout profiles and their correlates: a latent profile analysis of Chinese university students. [PDF]

Front Psychol
Li Y, Li Y, Ye X, Yan S.
europepmc   +1 more source

A latent profile analysis of hierarchical management of supportive care needs in patients undergoing maintenance hemodialysis. [PDF]

Sci Rep
Li X, Li H, Li J, Fan Y.
europepmc   +1 more source