Results 31 to 40 of about 99,241 (260)

Personality profile analysis, personality-intelligence profile analysis, and the intergenerational transmission of both: Insights from Chinese evidence

Acta Psychologica
An individual-centered latent personality profile analysis represents a novel approach to personality research. Leveraging the China Family Panel Studies (CFPS) dataset, this study utilizes latent profile analysis to examine the Big Five personality ...
Mingjun Wang
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Fostering Playfulness in 2-to-6-Year-Old Children: A Longitudinal Study of Parental Play Support Profiles and Their Effects on Children’s Playfulness

Behavioral Sciences
Parental play support is crucial to children’s playfulness. Using a person-centered approach, we identified profiles of parental play support based on self-assessed roles.
Isabelle Duss, Cornelia Rüdisüli, Corina Wustmann Seiler, Patricia Lannen   +3 more
doaj   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

Burnout Profiles Among Young Researchers: A Latent Profile Analysis

Frontiers in Psychology, 2022
IntroductionBurnout is a growing problem among young researchers, affecting individuals, organizations and society. Our study aims to identify burnout profiles and highlight the corresponding job demands and resources, resulting in recommendations to ...
Anke Boone, Tinne Vander Elst, Tinne Vander Elst, Tinne Vander Elst, Sofie Vandenbroeck, Sofie Vandenbroeck, Lode Godderis, Lode Godderis   +7 more
doaj   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Examining Black girls’ mathematics and science dispositions using large-scale assessment and survey data: A QuantCrit framework

Methods in Psychology
Early exposure to mathematics and science is vital for fostering interest in STEM. However, gender and racial inequities are embedded barriers within education systems, particularly affecting young Black girls. This study draws from a QuantCrit framework,
Thao T. Vo, Shenghai Dai, Brian F. French   +2 more
doaj   +1 more source

Characterizing the heterogeneity of clinician practice use in community mental health using latent profile analysis

BMC Psychiatry, 2019
Background The behavioral health service provider population is highly heterogeneous. However, it is rarely treated as such within evidence-based practice implementation efforts.
Emily M. Becker-Haimes, Viktor Lushin, Torrey A. Creed, Rinad S. Beidas   +3 more
doaj   +1 more source