Results 51 to 60 of about 409,589 (330)

Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

FEBS Open Bio, EarlyView.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel, Sam Bennett, Natalie Ehlinger, Nelson Cook, Katelyn Marvin, Caleb L. Lines, Sam Reyes, Brooke Kirby, Shawn M. Ellerbroek   +8 more
wiley   +1 more source

Fostering Playfulness in 2-to-6-Year-Old Children: A Longitudinal Study of Parental Play Support Profiles and Their Effects on Children’s Playfulness

Behavioral Sciences
Parental play support is crucial to children’s playfulness. Using a person-centered approach, we identified profiles of parental play support based on self-assessed roles.
Isabelle Duss, Cornelia Rüdisüli, Corina Wustmann Seiler, Patricia Lannen   +3 more
doaj   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

Burnout Profiles Among Young Researchers: A Latent Profile Analysis

Frontiers in Psychology, 2022
IntroductionBurnout is a growing problem among young researchers, affecting individuals, organizations and society. Our study aims to identify burnout profiles and highlight the corresponding job demands and resources, resulting in recommendations to ...
Anke Boone, Tinne Vander Elst, Tinne Vander Elst, Tinne Vander Elst, Sofie Vandenbroeck, Sofie Vandenbroeck, Lode Godderis, Lode Godderis   +7 more
doaj   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

QTL linkage analysis of connected populations using ancestral marker and pedigree information [PDF]

, 2012
The common assumption in quantitative trait locus (QTL) linkage mapping studies that parents of multiple connected populations are unrelated is unrealistic for many plant breeding programs.
Bink, M.C.A.M., Radu Totir, L., Braak, C.J.F., ter, Winkler, C.R., Boer, M.P., Smith, O.S.   +5 more
core   +2 more sources

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

FEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source

Characterizing the heterogeneity of clinician practice use in community mental health using latent profile analysis

BMC Psychiatry, 2019
Background The behavioral health service provider population is highly heterogeneous. However, it is rarely treated as such within evidence-based practice implementation efforts.
Emily M. Becker-Haimes, Viktor Lushin, Torrey A. Creed, Rinad S. Beidas   +3 more
doaj   +1 more source

Maternal postpartum depression literacy subtypes: A latent profile analysis

Heliyon, 2023
Aim: To explore the potential categories and characteristic differences of maternal postpartum depression literacy. Design: Cross-sectional survey. Methods: From February 2023 to April 2023, convenience sampling was used to survey 278 women attending ...
Kangfen Li, Jie Lu, Yan Pang, Xinlie Zheng, Ran Liu, Min Ren, Suhua Tu   +6 more
doaj   +1 more source

Chromatin Profiles of Chromosomally Integrated Human Herpesvirus-6A [PDF]

, 2019
Human herpesvirus-6A (HHV-6A) and 6B (HHV-6B) are two closely related betaherpesviruses that are associated with various diseases including seizures and encephalitis.
Boyd, Joseph R., Dubuc, Isabelle, Flamand, Louis, Frietze, Seth, Gerrard, Diana L., Gravel, Annie, Kaufer, Benedikt B., Mariani P., Michael, Morissette, Guillaume, Saviola, Anthony J., Signorelli, Sylvia A., Wight, Darren J., Zimmermann, Cosima   +12 more
core   +1 more source