Results 61 to 70 of about 409,589 (330)

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Examining Black girls’ mathematics and science dispositions using large-scale assessment and survey data: A QuantCrit framework

Methods in Psychology
Early exposure to mathematics and science is vital for fostering interest in STEM. However, gender and racial inequities are embedded barriers within education systems, particularly affecting young Black girls. This study draws from a QuantCrit framework,
Thao T. Vo, Shenghai Dai, Brian F. French   +2 more
doaj   +1 more source

SHINE: Signed Heterogeneous Information Network Embedding for Sentiment Link Prediction

, 2017
In online social networks people often express attitudes towards others, which forms massive sentiment links among users. Predicting the sign of sentiment links is a fundamental task in many areas such as personal advertising and public opinion analysis.
Guo, Minyi, Hou, Min, Liu, Qi, Wang, Hongwei, Xie, Xing, Zhang, Fuzheng   +5 more
core   +1 more source

Subgroups of relational job characteristics and their differences in turnover intention and subjective well-being among nurses: a latent profile analysis [PDF]

, 2023
Yiping Chen, Yifei Li, Jie Zhang, Juan Li, Xiufen Yang, Lile Xiong, Guili Xia, Jingping Zhang   +7 more
openalex   +1 more source

Clustering Algorithm Reveals Dopamine‐Motor Mismatch in Cognitively Preserved Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore the relationship between dopaminergic denervation and motor impairment in two de novo Parkinson's disease (PD) cohorts. Methods n = 249 PD patients from Parkinson's Progression Markers Initiative (PPMI) and n = 84 from an external clinical cohort.
Rachele Malito, Chiara Meneghini, Alice Galli, Luca Gallo, Pierfrancesco Mitrotti, Paola Dimartino, Marianna Inglese, Cinzia Zatti, Alessandro Lupini, Andrea Pilotto, Alessandro Padovani, Micol Avenali, Enza Maria Valente, Cristina Tassorelli, Silvia P. Caminiti   +14 more
wiley   +1 more source

The mid-infrared spectrum of the transiting exoplanet HD 209458b [PDF]

, 2007
We report the spectroscopic detection of mid-infrared emission from the transiting exoplanet HD 209458b. Using archive data taken with the Spitzer/IRS instrument, we have determined the spectrum of HD 209458b between 7.46 and 15.25 microns.
Akeson, R., Beichman, C., Bouwman, J., Lawler, S., Swain, M. R.   +4 more
core   +2 more sources

Multidimensional Profiling of MRI‐Negative Temporal Lobe Epilepsy Uncovers Distinct Phenotypes

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Although hippocampal sclerosis (TLE‐HS) represents the most frequent cause of temporal lobe epilepsy (TLE), up to 30% of patients show no lesion on visual MRI inspection (TLE‐MRIneg). These cases pose diagnostic and therapeutic challenges and are underrepresented in surgical series.
Alice Ballerini, Alessia Casarini, Niccolò Biagioli, Laura Mirandola, Daniela Ballotta, Paul Summers, Simona Scolastico, Laura Madrassi, Maurilio Genovese, Marcella Malagoli, Gaetano Cantalupo, Giada Giovannini, Matteo Pugnaghi, Niccolò Orlandi, Laura Tassi, Valeria Cuccarini, Domenico Aquino, Elena Tartara, Fulvia Palesi, Giuseppe Didato, Paolo Vitali, the 3TLE Study Group, Roberta Di Giacomo, Fabio Doniselli, Federica Mazzi, Carlo Andrea Galimberti, Claudia A. M. Gandini Wheeler‐Kingshott, Stefano Meletti, Anna Elisabetta Vaudano   +28 more
wiley   +1 more source

Identification of distinct symptom profiles in primary brain tumor patients: a prospective longitudinal study

BMC Neurology
Background Symptom burden in primary brain tumor patients varies, emphasizing the need for comprehensive understanding to improve patient care. This study aims to identify distinct symptom clusters among brain tumor patients in Shanghai, China, using ...
Rongqing Li, Zikai Zhang, Xin Zhang, Jiefang Song, Yawen Wu, Linzhi Wu, Sailu Mao, Jinxia Jiang, Li Zeng   +8 more
doaj   +1 more source

White Matter Hyperintensity Burden and Short‐Interval Change Associated With Sleep Apnoea in the UK Biobank

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Purpose White matter hyperintensities (WMH) are a core neuroimaging marker of cerebral small vessel disease (CSVD). Sleep apnoea (SA) is a recognized vascular risk factor, but its associations with regional WMH burden, short‐interval WMH change and cognitive performance in population‐based cohorts remain incompletely defined. We
Peng Cheng, Diego Z. Carvalho, Shahid Karim, Anwar Chahal, Virend K. Somers   +4 more
wiley   +1 more source

A network analysis of the heterogeneity and associated risk and protective factors of depression and anxiety among college students

Scientific Reports
Background: Comorbidity of depression and anxiety is common among adolescents and can lead to adverse outcomes. However, there is limited understanding of the latent characteristics and mechanisms governing these disorders and their interactions ...
Chunjuan Niu, Yaye Jiang, Yihui Li, Xudong Wang, Huiyuan Zhao, Zhengshu Cheng, Xiaoran Li, Xu Zhang, Zhiwei Liu, Xiaoyu Yu, Yan Peng   +10 more
doaj   +1 more source