Results 51 to 60 of about 516,217 (284)

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

Latent Class Analysis to Represent Social Determinant of Health Risk Groups in the Medicaid Cohort of the District of Columbia

Medical Care, 2020
Objective: To develop distinct social risk profiles based on social determinants of health (SDH) information and to determine whether these social risk groups varied in terms of health, health care utilization, and costs. Methods: We prospectively enrolled 8943 beneficiaries insured
Melissa L, McCarthy, Zhaonian, Zheng, Marcee E, Wilder, Angelo, Elmi, Paige, Kulie, Samuel, Johnson, Scott L, Zeger   +6 more
openaire   +3 more sources

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Consumer heterogeneity evolving from social group dynamics: Latent class analyses of German footwear consumption 1980–1991 [PDF]

Journal of Business Research, 2007
Abstract Boundedly rational consumers rely on their social environment as a source of information. Drawing upon psychological theories about social comparison processes, the author hypothesizes that social reference groups underlie market segments.
openaire   +2 more sources

Online social capital : mood, topical and psycholinguistic analysis [PDF]

, 2013
Social media provides rich sources of personal information and community interaction which can be linked to aspect of mental health. In this paper we investigate manifest properties of textual messages, including latent topics, psycholinguistic features,
Berk, Michael, Dao, Bo, Nguyen, Thin, Phung, Dinh, Venkatesh, Svetha   +4 more
core  

Clustering Algorithm Reveals Dopamine‐Motor Mismatch in Cognitively Preserved Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore the relationship between dopaminergic denervation and motor impairment in two de novo Parkinson's disease (PD) cohorts. Methods n = 249 PD patients from Parkinson's Progression Markers Initiative (PPMI) and n = 84 from an external clinical cohort.
Rachele Malito, Chiara Meneghini, Alice Galli, Luca Gallo, Pierfrancesco Mitrotti, Paola Dimartino, Marianna Inglese, Cinzia Zatti, Alessandro Lupini, Andrea Pilotto, Alessandro Padovani, Micol Avenali, Enza Maria Valente, Cristina Tassorelli, Silvia P. Caminiti   +14 more
wiley   +1 more source

Discourse, Difference, and Divergence: Exploring Media Representations and Online Public Sentiments toward Marginalized Urban Communities in Jamaica during the COVID-19 Pandemic

Social Sciences, 2022
Despite lacking the resources to adequately adhere to public health protocols, urban residents belonging to impoverished communities in Kingston, Jamaica were prominently featured in local news reports that highlighted their breaches of social distancing.
Aleem Mahabir, Romario Anderson, Robert Kinlocke, Rose-Ann Smith, Kristinia Doughorty, Chandradath Madho   +5 more
doaj   +1 more source

Multidimensional Profiling of MRI‐Negative Temporal Lobe Epilepsy Uncovers Distinct Phenotypes

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Although hippocampal sclerosis (TLE‐HS) represents the most frequent cause of temporal lobe epilepsy (TLE), up to 30% of patients show no lesion on visual MRI inspection (TLE‐MRIneg). These cases pose diagnostic and therapeutic challenges and are underrepresented in surgical series.
Alice Ballerini, Alessia Casarini, Niccolò Biagioli, Laura Mirandola, Daniela Ballotta, Paul Summers, Simona Scolastico, Laura Madrassi, Maurilio Genovese, Marcella Malagoli, Gaetano Cantalupo, Giada Giovannini, Matteo Pugnaghi, Niccolò Orlandi, Laura Tassi, Valeria Cuccarini, Domenico Aquino, Elena Tartara, Fulvia Palesi, Giuseppe Didato, Paolo Vitali, the 3TLE Study Group, Roberta Di Giacomo, Fabio Doniselli, Federica Mazzi, Carlo Andrea Galimberti, Claudia A. M. Gandini Wheeler‐Kingshott, Stefano Meletti, Anna Elisabetta Vaudano   +28 more
wiley   +1 more source

Potentials and Pitfalls of Self‐Help Tools: A Survey Study of Digital Psychiatry in Denmark

Social Inclusion
Welfare systems around the world are struggling to cope with the growing number of people needing psychiatric care. Consequently, digitalization has become a beacon of hope, making treatment more accessible and bolstering patient empowerment.
Emilie Kristine Dyrlev
doaj   +1 more source

Latent characteristics and preferences for income redistribution [PDF]

, 2015
Due to reasons such as the capacity to govern and social stability a good understanding of citizens preferences and their informal coalitions is extremely important. Because preferences for redistribution are difficult to measure identification of latent
Mørkbak, Morten Raun, Pfarr, Christian, Schmid, Andreas   +2 more
core