Results 61 to 70 of about 516,217 (284)

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

Added Prognostic Value of EEG Reactivity in Comatose Patients Following Cardiac Arrest

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives To evaluate the added prognostic value of EEG reactivity for favorable outcome compared with background analysis during and after targeted temperature management (TTM). Methods Prospective observational cohort study of comatose post–cardiac arrest patients admitted to a single academic center between 2017 and 2022, all undergoing ...
Sarah Caroyer, Marie Obrecht, Charlotte de Maeseneire, Charlotte Damien, Chantal Depondt, Lorenzo Ferlini, Estelle Rikir, Filippo Annoni, Fabio Silvio Taccone, Nicolas Mavroudakis, Benjamin Legros, Nicolas Gaspard   +11 more
wiley   +1 more source

Benefit finding in individuals undergoing maintenance hemodialysis in Shanghai: a latent profile analysis

Frontiers in Psychology
ObjectiveThis multi-center cross-sectional study aimed to delineate latent profiles of benefit finding (BF) in individuals undergoing maintenance hemodialysis (MHD) in Shanghai and examine associations between these BF profiles, social support, and ...
Jie Yang, Yong-qi Li, Yan-lin Gong, Hong-li Yan, Jing Chen, Ling-ling Liu, Jing Wu, Jing Chu   +7 more
doaj   +1 more source

Joint Topic-Semantic-aware Social Recommendation for Online Voting

, 2017
Online voting is an emerging feature in social networks, in which users can express their attitudes toward various issues and show their unique interest.
Cao, Jiannong, Guo, Minyi, Wang, Hongwei, Wang, Jia, Zhao, Miao   +4 more
core   +1 more source

Movement Disorders in Aicardi–Goutières Syndrome and Response to Immunomodulation

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT This study characterizes movement disorders and treatment responses in seven children with Aicardi–Goutières syndrome (AGS). We retrospectively evaluated motor phenotypes, neuroimaging, and interferon signatures in patients treated with baricitinib or anifrolumab. Spasticity affected all patients, while dystonia was present in 4/7.
Enrique Gonzalez Saez‐Diez, Monica Ferrer Socorro, Kathryn Yang, Nicole Battaglia, Zainab Zaman, Mariko Bennett, Adeline Vanderver, Pui Y. Lee, Lauren A. Henderson, Milena M. Andzelm, Darius Ebrahimi‐Fakhari   +10 more
wiley   +1 more source

Development and validation of a social alienation predictive model for older maintenance hemodialysis patients based on latent profile analysis—a cross-sectional study

BMC Geriatrics
Background Social alienation refers to the state of feeling isolated, helpless, and unsatisfied due to maintaining distance from others or avoiding social interaction and activities.
Guannan Wang, Jing Dong, Na Zhu, Yiping Zhu   +3 more
doaj   +1 more source

Differences in fear of failure and college adjustment by type of medical school entrance extrinsic motivation using a latent profile analysis [PDF]

Korean Journal of Medical Education
Purpose The decision to enroll in medical school is largely influenced by extrinsic motivation factors. It is necessary to explore the factors that affect pre-med students’ motivation to enter medical school and their college adjustment, and to develop ...
So Jung Yune, Ie Byung Park, Hyo Hyun Yoo, Kwi Hwa Park   +3 more
doaj   +1 more source

Social and behavioural risk factors in the prevention and management of cardiovascular disease in Kerala, India: a catchment area population survey

BMC Cardiovascular Disorders, 2020
Background Cardiovascular disease (CVD) is the leading cause of mortality in India. Social and behavioural factors are strongly interrelated in the prevention and control of CVD. The ability to make lifestyle changes to control hypertension and diabetes (
Saju Madavanakadu Devassy, Martin Webber, Lorane Scaria, Jotheeswaran Amuthavalli Thiyagarajan, Meredith Fendt-Newlin, Jacques Joubert, Anuja Maria Benny, Anjana Nannatt, Lynette Joubert   +8 more
doaj   +1 more source

Latent Social Groups: Phenomenon, Evolution, Research Prospects

Bulletin of Practical Psychology of Education
<p style="text-align: justify;">Purpose of the study: to study and describe the phenomenon of LSG (latent social groups). Hypotheses: 1) The basis for the emergence of LSG as pre-forms are the subjective preferences of a person (&ldquo;deep&rdquo; personal formations formed by the conditions of the internal and external environment). 2) A
openaire   +1 more source

Preferences for Posttraumatic Osteoarthritis Prevention Strategies in Individuals With Anterior Cruciate Ligament Injury

Arthritis Care &Research, EarlyView.
Objective There is growing interest in evaluating new strategies to delay or prevent posttraumatic osteoarthritis (PTOA) in individuals who have sustained anterior cruciate ligament (ACL) injury. This study sought to determine characteristics of potential treatments that are acceptable to patients with ACL injury. Methods Participants with a history of
Kevin Kennedy, Lily Waddell, Adam Easterbrook, Jeffrey N. Katz, Cale Jacobs, Morgan Jones, Faith Selzer, Elena Losina, Liana Fraenkel, Nick Bansback   +9 more
wiley   +1 more source