Results 41 to 50 of about 25,555 (257)

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

open access: yesMolecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

THEORETICAL AND PRACTICAL ASPECTS OF IDENTIFICATION AND EVALUATION OF SCHOOL EDUCATION QUALITY

open access: yesОбразование и наука, 2015
The paper considers one of the main theoretical and practical pedagogical problems of education quality assessment. The quality measurement depends on successful identification of genuine (scientific) and false diagnostic methods; the process becomes ...
N. Y. Yerganova   +2 more
doaj   +1 more source

Spectral quantitative and semi-quantitative EEG provide complementary information on the life-long effects of early childhood malnutrition on cognitive decline

open access: yesFrontiers in Neuroscience, 2023
ObjectiveThis study compares the complementary information from semi-quantitative EEG (sqEEG) and spectral quantitative EEG (spectral-qEEG) to detect the life-long effects of early childhood malnutrition on the brain.MethodsResting-state EEGs (N = 202 ...
Fuleah A. Razzaq   +19 more
doaj   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant   +11 more
wiley   +1 more source

Latent classes of delinquent behaviour associated with criminal social identity among juvenile offenders in Pakistan [PDF]

open access: yes, 2015
© Emerald Group Publishing Limited. Purpose – The purpose of this paper is to examine the number and nature of latent classes of delinquency that exist among male juvenile offenders incarcerated in prisons in Pakistan.
Dhingra, Katie   +8 more
core   +1 more source

Embedded Generative Air Pollution Model with Variational Autoencoder and Environmental Factor Effect in Ulaanbaatar City

open access: yesAtmosphere, 2021
Air pollution is one of the most pressing modern-day issues in cities around the world. However, most cities have adopted air quality measurement devices that only measure the past pollution levels without paying attention to the influencing factors.
Bulgansaikhan Baldorj   +3 more
doaj   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

open access: yesFEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee   +6 more
wiley   +1 more source

A Bilateral Comparison of Fruit and Vegetable Consumption: United States and Canada

open access: yesJournal of Agricultural and Resource Economics, 2005
Many public programs promote diets rich in fruits and vegetables based on evidence of the derived health benefits. Still, produce consumption in the United States lags behind other nations, even its most culturally similar neighbor--Canada.
Timothy J. Richards, Paul M. Patterson
doaj   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

open access: yesFEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin   +3 more
wiley   +1 more source

Developing a Variation Index for Understanding Step Characteristics in the Long Jump Approach Run

open access: yesPhysical Education Theory and Methodology
Objectives.  The prime objective of the study was to develop a new variation index that can be used to identify the mechanical variations in the step pattern of the approach run. Materials and methods.
Ankur Jyoti Phukon, Krishnendu Dhar
doaj   +1 more source

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