Results 41 to 50 of about 4,736,396 (308)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Numerical Investigation on Handling Stability of a Heavy Tractor Semi-Trailer under Crosswind

Applied Sciences, 2020
Due to the large lateral area of the trailer and variable road conditions, the handling stability of a heavy tractor semi-trailer under crosswind is very important for road safety.
Qianwen Zhang, Chuqi Su, Yi Zhou, Chengcai Zhang, Jiuyang Ding, Yiping Wang   +5 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Vehicle lateral dynamics estimation using unknown input observer

Procedia Computer Science, 2019
This paper introduces an approach for estimating the parameters of the vehicle dynamics using a fuzzy Unknown Input Observer (UIO). The nonlinear model used has been deduced from the vehicle dynamics with a vision system is represented by a Takagi-Sugeno
Naoufal El Youssfi, M. Oudghiri, Rachid El Bachtiri   +2 more
semanticscholar   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Spectral Analysis of the Lateral Dynamics of Road Vehicles

Engineering Proceedings
In this paper, a time domain and a spectral analysis of the lateral dynamics of a Lexus passenger car are presented. Measurements were made of the vehicle’s lateral acceleration and steering angle. The aim of the measurements is to understand the vehicle’
György Istenes, Gergő Ferenc Ignéczi, Dávid Józsa, Dániel Pup, József Bokor   +4 more
doaj   +1 more source

Vehicle lateral dynamics stabilization using active suspension [PDF]

Applied and Computational Mechanics, 2008
The paper deals with the investigation of active nonlinear suspension control in order to stabilize the lateral vehicle motion in similar way as systems like ESP do.
Drobný V., Valášek M.
doaj  

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Operation Effect Analysis of Dynamic Stabilizer Considering the Characteristics of Fasteners

Chengshi guidao jiaotong yanjiu
［Objective］ Research is conducted on the influence and significance of the excitation frequency of the dynamic stabilization device and the mechanical characteristics of rail fasteners on the operation effect of the dynamic track stabilizer in order to ...
CHEN Taimao, WANG Lihua, HUANG Hongyi, WANG Jiongli, ZHAO Zemin, JIANG Wei   +5 more
doaj   +1 more source