Characterizing Cutaneous α‐Synuclein Deposition and Seeding Activity in Parkinson's Disease Subtypes
ABSTRACT Objective Cutaneous phosphorylated α‐synuclein (p‐syn) and α‐synuclein seeding activity are promising biomarkers for Parkinson's disease (PD), but their clinical value remains uncertain due to disease heterogeneity. This study evaluates these two biomarkers in PD patients to inform phenotype‐specific diagnosis and disease severity assessment ...
Yuting Jin +8 more
wiley +1 more source
Influence of Track Exponential Decay Type Local Dynamic Irregularity on Locomotive Performance
Based on the vehicle system dynamics theory, exponential decay type dynamic irregularity was simulated as the locomotive model external excitation by using MATLAB software.
JIANG Bo +3 more
doaj
Although previous studies have considered sensing constraints and UAV dynamics, most of them have used unrealistic sensing limitations and simplified dynamic models.
Soobin Huh +5 more
doaj +1 more source
Calibration and Improvement of an Odometry Model with Dynamic Wheel and Lateral Dynamics Integration. [PDF]
Fazekas M, Gáspár P, Németh B.
europepmc +1 more source
Fault diagnosis for vehicle lateral dynamics with robust threshold
This paper investigates the robust fault diagnosis problem for vehicle lateral dynamics, which play a key role in vehicle stability and driving safety. The proposed fault diagnosis system consists of two sub-systems: fault diagnosis observer and robust ...
Jinya Su, Wen‐Hua Chen
semanticscholar +1 more source
Natural Frequencies of Levodopa‐Induced Dyskinesia in Parkinson's Disease
ABSTRACT Objectives Abnormal involuntary movements, known as dyskinesias, are common complications of levodopa treatment in patients with Parkinson's disease and can significantly impair quality of life. The underlying pathophysiology remains unclear, and current therapeutic options are limited.
Ioannis U. Isaias +3 more
wiley +1 more source
Dynamics Performance Analysis of Turntable Bogie Vehicles
Objective Compared to conventional bogies, the new type of turntable bogie exhibits smaller slewing resistance coefficients and better curve negotiation performance. Therefore, it is necessary to analyze the vehicle dynamics performance.
HU Dingxiang +4 more
doaj +1 more source
Stage‐Dependent β‐Synuclein Links MRI and Cognitive Decline in Alzheimer's Disease
ABSTRACT Objective Synaptic degeneration drives cognitive decline in Alzheimer's disease (AD), but synaptic biomarkers are scarce. Brain‐enriched β‐synuclein emerged as a synaptic damage marker. We investigated its diagnostic, prognostic, and structural correlates across the AD continuum.
Ulaş Ay +15 more
wiley +1 more source
Dynamics Performance Analysis of Metro Vehicle-Turnout System Based on Rigid-Flexible Coupled Model
[Objective] To investigate the safety of metro vehicles passing through No.12 turnouts in both lateral and forward directions, providing a theoretical basis for the optimization and maintenance of turnout structures, it is necessary to study the dynamic ...
LI Huawei, XU Xiaotang, LIU Wei, HE Jun
doaj +1 more source
Long-term positioning and polar preference of chemoreceptor clusters in E. coli
Bacterial chemoreceptors form clusters, preferably at the cell poles. Here, Koler et al. show that polar and lateral clusters exhibit distinct long-term positional dynamics and that polar bias may be due to differences in mobility of receptor ...
Moriah Koler +4 more
doaj +1 more source

