Results 271 to 280 of about 230,314 (320)

Injectable and In Situ Hydration‐Reinforced Hybrid Bone Cements for Accelerated Bone Regeneration

open access: yesAdvanced Science, EarlyView.
To enable minimally invasive bone defect repair, an injectable and hydration‐reinforced bone cement (L‐PEGS/CPC) is designed through biomimetic reconstruction. The hydrophilic L‐PEGS organic phase provides abundant nucleation sites, synergizing with its porous architecture to accelerate CPC hydration, thereby endowing the composite with exceptional ...
Xing Chen   +7 more
wiley   +1 more source

Proteogenomic Characterization Reveals Subtype‐Specific Therapeutic Potential for HER2‐Low Breast Cancer

open access: yesAdvanced Science, EarlyView.
Multiomic profiling of HER2‐low breast cancer identifies three proteomic subtypes with distinct therapeutic strategies: endocrine, antiangiogenic, and anti‐HER2 therapies. Genomic and lactate modification landscapes are detailed, providing insights for precise management.
Shouping Xu   +20 more
wiley   +1 more source

Brillouin Microscopy of Breast tumor Spheroids On‐a‐Chip: Mechanical and Transcriptional Responses to Microfluidic‐Induced Rapid Deformations

open access: yesAdvanced Science, EarlyView.
Brillouin‐Raman Microspectroscopy on‐a‐Chip (BRmS) enables real‐time analysis of breast tumor spheroids in microfluidic channels. Following cyclical deformations, MCF10.DCIS.com spheroids are captured in recovery traps and imaged with BRmS. The applied deformations trigger a stiffening response marked by increased frequency shifts, elevation of the ...
Mona Makkieh   +22 more
wiley   +1 more source

Establishment and maintenance of NRT2.1 inter-individual variability in plants. [PDF]

open access: yesPLoS Genet
Lecuyer C   +7 more
europepmc   +1 more source

Detecting Laterally Transferred Genes

2012
Methods for identifying alien genes in genomes fall into two general classes. Phylogenetic methods examine the distribution of a gene's homologues among genomes to find those with relationships not consistent with vertical inheritance. These approaches include identifying orphan genes which lack homologues in closely related genomes and genes with ...
Rajeev K, Azad, Jeffrey G, Lawrence
openaire   +2 more sources

Lateral gene transfer in Salmonella

Microbes and Infection, 2003
Comparative genomics and microarrays reveal that the genomes of different Salmonella enterica serovars are distinguished from each other by the presence or absence of hundreds of genes. The distribution of these variable genome regions is often not clonal.
Steffen, Porwollik, Michael, McClelland
openaire   +2 more sources

TOWARDS IDENTIFYING LATERAL GENE TRANSFER EVENTS

Biocomputing 2003, 2002
This paper is concerned with evaluating the performance of the model and algorithm in 5 for detecting lateral gene transfers events. Using a Poisson process to describe arrival times of transfer events, a simulation is used to generate "synthetic" gene and species trees.
L, Addario-Berry   +2 more
openaire   +2 more sources

Phylogenetic reconstruction and lateral gene transfer

Trends in Microbiology, 2004
Lateral gene transfer (LGT) is often seen as a form of noise, obscuring the phylogenetic signal with which we might hope to reconstruct the evolution of a group of organisms, or indeed the history of all life (the Tree of Life). Such reconstruction might still be possible if the subset of genes conserved among all genomes in a group (or common to all ...
Eric, Bapteste   +3 more
openaire   +2 more sources

Relative Time Inference Using Lateral Gene Transfers

2022
Many organisms are able to incorporate exogenous DNA into their genomes. This process, called lateral gene transfer (LGT), has the potential to benefit the recipient organism by providing useful coding sequences, such as antibiotic resistance genes or enzymes which expand the organism's metabolic niche. For evolutionary biologists, LGTs have often been
Adrián A, Davín   +4 more
openaire   +2 more sources

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