Results 41 to 50 of about 521,360 (305)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Multi-objective optimization of outriggers in high-rise buildings subjected to wind loads

Revista IBRACON de Estruturas e Materiais, 2022
: This paper aims to investigate a methodology for determining the optimum floor positioning of outriggers (ORs) and belt-trusses (BTs) over tall buildings height.
Felipe Morrone Barbat Parfitt, Inácio Benvegnu Morsch, Herbert Martins Gomes   +2 more
doaj   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

A nonlinear finite element model of lightweight walls with cold formed steel members under lateral load

Revista Facultad de Ingeniería Universidad de Antioquia, 2014
This article presents the results of an investigation aimed at generating finite element models (FEM) for studying lateral load behavior of lightweight walls composed of a typical steel framing and different coating materials.
Carlos Andrés Gaviria M., Aydée Patricia Guerrero Z., Peter Thomson R.   +2 more
doaj   +1 more source

Acoustic Measures Capture Speech Dysfunction in Spinocerebellar Ataxia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Spinocerebellar ataxias (SCA) are hereditary cerebellar degenerative disorders with a common feature of dysarthria, involving impaired phonatory and articulatory control of speech, thereby affecting social communication. In this study, we investigated whether acoustic measures could objectively measure speech dysfunction and identify
Zena Fadel, Charlotte Hennessey, Hannah Lee, Pia Parekh, Sheng‐Han Kuo, Ami Kumar   +5 more
wiley   +1 more source

Shear critical R/C columns under increasing axial load [PDF]

, 2020
Structural elements in old reinforced concrete (R/C) frame buildings are often prone to shear or flexure-shear failure, which can eventually lead to loss of axial load capacity of vertical elements and initiate vertical progressive collapse of a building.
Elwood, Ghannoum, Ghannoum, Izzuddin, Lew, Lynn, Murray, Ousalem, Sasani, Sezen, Sezen, Xu, Yu, Zimos, Zimos   +14 more
core   +2 more sources

Association of Corticospinal Tract Asymmetry With Ambulatory Ability After Intracerebral Hemorrhage

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Ambulatory ability after intracerebral hemorrhage (ICH) is important to patients. We tested whether asymmetry between ipsi‐ and contra‐lesional corticospinal tracts (CSTs) assessed by diffusion tensor imaging (DTI) is associated with post‐ICH ambulation.
Yasmin N. Aziz, Carl D. Langefeld, Mary E. Comeau, Miranda C. Marion, Tyler P. Behymer, Lee A. Gilkerson, Padmini Sekar, Weihong Yuan, Vivek Khandwala, Brady J. Williamson, Thomas Maloney, Achala Vagal, Pierce Boyne, Kari Dunning, Matthew L. Flaherty, Steven J. Kittner, Prachi Mehndiratta, Gunjan Y. Parikh, Michael L. James, David Roh, Fernando D. Testai, Farhaan S. Vahidy, James Thornton, Ranjit Bagga, Daniel Woo, Stacie L. Demel   +25 more
wiley   +1 more source

STUDY OF NONLINEAR STATIC PUSHOVER ANALYSES DUE TO LATERAL LOAD PATTERNS [PDF]

, 2012
STUDY OF NONLINEAR STATIC PUSHOVER ANALYSES DUE TO LATERAL LOAD PATTERNS, Rosalia Widyaningsih, Student Number 061312590, 2012, Structure, International Civil Engineering, Department of Civil Engineering, Atma Jaya Yogyakarta University.
WIDYANINGSIH, ROSALIA
core  

Optimization of force-limiting seismic devices connecting structural subsystems [PDF]

, 2016
This paper is focused on the optimum design of an original force-limiting floor anchorage system for the seismic protection of reinforced concrete (RC) dual wall-frame buildings.
Fleischman, Robert B., Marano, Giuseppe C., Monti, Giorgio, Quaranta, Giuseppe, Scodeggio, Alessandro   +4 more
core   +1 more source

Functional Connectivity Linked to Cognitive Recovery After Minor Stroke

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Patients with minor stroke exhibit slowed processing speed and generalized alterations in functional connectivity involving frontoparietal cortex (FPC). The pattern of connectivity evolves over time. In this study, we examine the relationship of functional connectivity patterns to cognitive performance, to determine ...
Vrishab Commuri, Isabella Dallasta, Ciaran Stone, Sophia Girgenti, Neda Gould, Rafael H. Llinas, Jonathan Z. Simon, Elisabeth Breese Marsh   +7 more
wiley   +1 more source