Results 31 to 40 of about 145,933 (265)
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Lateral Load-Deflection Relationships of Piles Subjected to Dynamic Loadings
Soils and Foundations, 1980 ABSTRACT A simple representation of the dynamic lateral load-deflection relationship of a pile is presented for both pile-head and seismic excitation conditions. The lateral load-deflection relationship of a pile is represented by the soil reaction coefficient that is the ratio between a unit soil reaction on a pile and the product of soil modulus ...
KAGAWA, TAKAAKI, KRAFT, LELAND M.
openaire +2 more sources
FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
Lateral Cyclic Loading of Sand-Installed Piles
Soils and Foundations, 2007 The present study was conducted to examine the behaviour of instrumented flexible piles in dry sand under lateral cyclic loading using centrifuged models. Considering load service conditions, the influence of the number of cycles of their amplitude and of the soil density on the pile cap displacement and the maximum bending moment of the pile is ...
Rosquoet, Frédéric +3 more
openaire +3 more sources
FEBS Letters, EarlyView.Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara +3 more
wiley +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
BuildingsWalls in masonry structures exhibit sensitive behavior under out-of-plane displacements. Although numerous studies address in-plane behavior, research focusing on out-of-plane response remains limited.
Fırat Kıpçak
doaj +1 more source
Revista Facultad de Ingeniería Universidad de Antioquia, 2014 This article presents the results of an investigation aimed at generating finite element models (FEM) for studying lateral load behavior of lightweight walls composed of a typical steel framing and different coating materials.
Carlos Andrés Gaviria M. +2 more
doaj +1 more source
Static Design for Laterally Loaded Rigid Monopiles in Cohesive Soil
Journal of Marine Science and Engineering, 2023 Rigid monopiles with small slenderness ratios (i.e., ratio of monopile embedded length to outer diameter) are widely used as foundations to resist lateral load and moment transferred from superstructures, e.g., large diameter steel pipes used by offshore
Ruping Luo +4 more
doaj +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source