Results 41 to 50 of about 4,724,325 (351)
Stiffness of Contacts Between Rough Surfaces
, 2010 The effect of self-affine roughness on solid contact is examined with molecular dynamics and continuum calculations. The contact area and normal and lateral stiffnesses rise linearly with the applied load, and the load rises exponentially with decreasing
F. P. Bowden +4 more
core +1 more source
Force Performance Analysis of Pile Behavior of the Lateral Load
Infrastructures, 2019 This study was focused on the performance of the pile force at the lateral load of an arched bridge. The effect of the compression of arch bridges creates a large horizontal load.
Touré Youssouf +4 more
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Engineering structures, 2018 One of the common lateral load resisting systems in multi-story timber buildings in Central Europe are reinforced concrete shear walls. The RC shear walls are not optimal for timber buildings for several reasons such as: (i) the difference in tolerance ...
Abdollah Sadeghi Marzaleh +3 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Modelling and Assessment of a Single Pile Subjected to Lateral Load
Studia Geotechnica et Mechanica, 2018 A three-dimensional finite element technique was used to analyse single pile lateral response subjected to pure lateral load. The main objective of this study is to assess the influence of the pile slenderness ratio on the lateral behaviour of single ...
J. Abbas, Z. Chik, M. Taha
semanticscholar +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Monotonic and cyclic lateral load tests on driven piles in chalk [PDF]
, 2017 This paper describes the results of a pile-testing campaign on open-ended tubular steel instrumented piles driven into the Chalk formation in the UK. The testing campaign comprised the performance of both monotonic and one-way cyclic lateral load tests,
Carey, John +2 more
core +2 more sources