Results 41 to 50 of about 145,933 (265)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

In-Situ Experimental Study of Closed-Diaphragm Wall Foundations for Cross-Sea Suspension Bridges

Journal of Marine Science and Engineering
This study examines the in-situ lateral static load behavior of a closed-diaphragm wall foundation, aiming to better understand its load–displacement response, structural behavior, and soil interaction under horizontal loading.
Wenshuai Li, Qiyu Tao, Chao Li, Xin Wang, Weiming Gong, Guoliang Dai   +5 more
doaj   +1 more source

Seismic Performance Evaluation Of Momentresisting Steel Frames With Two Softwares

مجلة العلوم البحتة والتطبيقية, 2020
Moment resisting steel frames (MRSF); which are widely used as lateral load Resisting systems for low- to medium-rise buildings; are one of the simplest ductile systems that can be built without bracing elements.
Heba A. Fdiel , Rabie A. Amnisi
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Simplified Design Method of Laterally Loaded Rigid Monopiles in Cohesionless Soil

Journal of Marine Science and Engineering
This paper presents a simplified design method for laterally loaded rigid monopiles in cohesionless soil. The proposed design method is based on a constant depth of the rotation point and a bi-linear distribution of soil lateral reaction along the ...
Ruping Luo, Anhui Wang, Jie Li, Wenyun Ding, Bitang Zhu   +4 more
doaj   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Impact of the convergent geometric profile on boundary layer separation in the supersonic over-expanded nozzle

Open Physics, 2022
This article aims to conduct a numerical investigation of phenomena induced by gas expansion in chemical propulsion nozzles. A numerical simulation of full-scale flat convergent-divergent nozzle geometry using the finite volume method on structured ...
Dehane Rabie, Naima Khatir, Liazid Abdelkrim, Inc Mustafa, Benarous Abdallah, Ahmad Hijaz, Menni Younes   +6 more
doaj   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source