Results 71 to 80 of about 6,351,446 (338)

Integration of Serum Neurofilament Light Chain and Cortical Dysfunction Improves Diagnostic Accuracy in ALS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To determine whether integration of serum neurofilament light chain (NfL) and cortical dysfunction improves diagnostic accuracy in amyotrophic lateral sclerosis (ALS) when applied alongside the Gold Coast criteria (GCC). Methods In this prospective study, 148 participants with suspected ALS were recruited (101 ALS and 47 with ALS ...
Aicee Dawn Calma, Nathan Pavey, Yukiko Tsuji, Amirul Ab Ghapar, Mehdi A.J. van den Bos, Bronwen Orden, Grace Lee, Linda Mekhael, Julie Ryder, Cláudia Santos Silva, David McDonald, Fakhria Kakar, Con Yiannikas, Matthew C. Kiernan, David A. Brown, Parvathi Menon, Steve Vucic   +16 more
wiley   +1 more source

Levelness Analysis of Subsea Wellhead Subjected to Lateral Load

Shiyou jixie, 2019
To ensure the levelness of the subsea wellhead and make sure that it does not produce large inclination in deep water to avoid damage to the wellhead equipment, the surface conductor and cementing sheath that fix the subsea wellhead system are treated as
Zhong Gongxiang, Zhang Yankai, Zhang Weijie   +2 more
doaj  

Numerical Study of the Out-of-Plane Response of Dry-Stack Double-Wythe Brick Walls with Header Bricks

Buildings
Walls in masonry structures exhibit sensitive behavior under out-of-plane displacements. Although numerous studies address in-plane behavior, research focusing on out-of-plane response remains limited.
Fırat Kıpçak
doaj   +1 more source

Characterizing Cutaneous α‐Synuclein Deposition and Seeding Activity in Parkinson's Disease Subtypes

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cutaneous phosphorylated α‐synuclein (p‐syn) and α‐synuclein seeding activity are promising biomarkers for Parkinson's disease (PD), but their clinical value remains uncertain due to disease heterogeneity. This study evaluates these two biomarkers in PD patients to inform phenotype‐specific diagnosis and disease severity assessment ...
Yuting Jin, Tianyuan Yang, Minglei Liu, Haiyang Luo, Jing Yuan, Ke Zhang, Xinsheng Han, Jing Yang, Yuming Xu   +8 more
wiley   +1 more source

Steel Diaphragms in Prestressed Concrete Girder Bridges; TR-424, September 2004 [PDF]

, 2004
Over the years, bridge engineers have been concerned about the response of prestressed concrete (PC) girder bridges that had been hit by over-height vehicles or vehicle loads. When a bridge is struck by an over-height vehicle or vehicle load, usually the

core  

Stage‐Dependent β‐Synuclein Links MRI and Cognitive Decline in Alzheimer's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Synaptic degeneration drives cognitive decline in Alzheimer's disease (AD), but synaptic biomarkers are scarce. Brain‐enriched β‐synuclein emerged as a synaptic damage marker. We investigated its diagnostic, prognostic, and structural correlates across the AD continuum.
Ulaş Ay, Merve Alaylioglu, Erdi Sahin, Sanem Sultan Yoruk Oner, Gulce Iskan, Gulce Cosku Yilmaz Cakan, Gozde Kizilates‐Evin, Emre Hari, Elif Kurt, Erdinc Dursun, Basar Bilgic, Hasmet Hanagasi, Hakan Gurvit, Tamer Demiralp, Duygu Gezen‐Ak, Bedia Samanci   +15 more
wiley   +1 more source

In-Situ Experimental Study of Closed-Diaphragm Wall Foundations for Cross-Sea Suspension Bridges

Journal of Marine Science and Engineering
This study examines the in-situ lateral static load behavior of a closed-diaphragm wall foundation, aiming to better understand its load–displacement response, structural behavior, and soil interaction under horizontal loading.
Wenshuai Li, Qiyu Tao, Chao Li, Xin Wang, Weiming Gong, Guoliang Dai   +5 more
doaj   +1 more source

Piles Subjected to Torsional Cyclic Load: Numerical Analysis

Frontiers in Built Environment, 2019
Pile foundations supporting large structures (such as high-rise buildings, oil drilling platforms, bridges etc). are often subjected to eccentric lateral load (in addition to the vertical loads) due to the action of wind, waves, high speed traffic, and ...
Sanjay Shrawan Nimbalkar, Piyush Punetha, Sudip Basack, Mehdi Mirzababaei   +3 more
doaj   +1 more source

Optimum Lateral Load Distribution for Seismic Design of Nonlinear Shear-Buildings Considering Soil-Structure Interaction

, 2016
The lateral load distributions specified by seismic design provisions are primarily based on elastic behaviour of fixed-base structures without considering the effects of soil-structure-interaction (SSI).
B. Ganjavi, I. Hajirasouliha, A. Bolourchi   +2 more
semanticscholar   +1 more source

Troponin T and Neurofilament Light Chain Levels as Complementary Biomarkers of Disease Accumulation and Aggressiveness in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is a clinically heterogeneous neurodegenerative disease requiring reliable biomarkers to improve patient stratification and trial design. While serum neurofilament light chain (sNfL) reflects neuroaxonal stress and disease aggressiveness, troponin T (TnT) may capture complementary aspects of ...
Julia Sellin, Sofia Waldorf, Janina von der Gablentz, Torsten Grehl, Huelya Nazlican, Thomas Meyer, Julian Grosskreutz, Patrick Weydt, Sarah Bernsen   +8 more
wiley   +1 more source