Results 41 to 50 of about 242,398 (310)

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Analysis of the Elastic Large Deflection Behavior for Metal Plates under Nonuniformly Distributed Lateral Pressure with In-Plane Loads

Journal of Applied Mathematics, 2012
The Galerkin method is applied to analyze the elastic large deflection behavior of metal plates subject to a combination of in-plane loads such as biaxial loads, edge shear and biaxial inplane bending moments, and uniformly or nonuniformly distributed ...
Jeom Kee Paik, Ju Hye Park, Bong Ju Kim
doaj   +1 more source

An experimental study of the effect of lateral static load on cyclic response of pile group in sandy soil

Journal of the Mechanical Behavior of Materials, 2023
The application of two different lateral loads (i.e., the first is static and the other is cyclic load) at the same time to pile group seems a complex problem.
Gummar Amal S., Abbas Jasim M.
doaj   +1 more source

A Comprehensive Overview of the Clinical, Electrophysiological, and Neuroimaging Features of BPAN: Insights From a New Case Series

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Neurodegeneration with brain iron accumulation (NBIA) comprises a genetically and clinically heterogeneous group of rare neurological disorders characterized particularly by iron accumulation in the basal ganglia. To date, 15 genes have been associated with NBIA.
Seda Susgun, Ozgu Kizek, Sibel Aylin Ugur Iseri, Ibrahim Kamaci, Ayse Deniz Elmali, Pinar Iscen, Berfin Gulkaya Guzel, Gul Yalcin Cakmakli, Bulent Elibol, Berril Donmez, Raif Cakmur, Pinar Topaloglu, Turkish NBIA Study Group, Abdullah Acar, Ahmet Acarer, Arzu Karabay, Asuman Ali, Ayla Barlas, Aysegul Gunduz, Banu Ozen Barut, Baris Baslo, Bilge Kocer, Bilgehan Mus, Birsen Karaman, Burcu Gokce Cokal, Cem Ismail Kucukali, Cenk Akbostanci, Ceyhun Sayman, Cagla Turan, Dilek Ince Gunal, Ebru Bilge Dirik, Ebru Erzurumluoglu, Elif Kocasoy Orhan, Enes Demiryurek, Emrah Yucesan, Ercan Kose, Erdem Tuzun, Esen Saka Topcuoglu, Esra Okuyucu, Fatma Betul Ozdilek, Feriha Ozer, Gencer Genc, Gozde Unal, Gulay Kenangil, Gullu Tarhan, Gunes Kiziltan, Halil Onder, Hamit Genc, Hasmet Hanagasi, Hatice Yuksel, Hulya Apaydin, Koray Kirimtay, Mehmet Guney Senol, Melisa Kilic, Meltem Demirkiran, Mert Karaca, Miray Erdem, Muhammet Bilgehan Mus, Murat Gultekin, Nalan Capan, Nazan Karagoz Sakalli, Nazli Basak, Nihan Hande Akcakaya, Ozan Ezer, Ozge Uygun, Ozge Yilmaz Kuspeci, Ozgur Oztop Cakmak, Pervin Iseri, Petek Ballar Kirmizibayrak, Pinar Elkoca, Recep Alp, Remzi Yigiter, Rezzak Yilmaz, Sadika Ozdemir, Selda Keskin, Selen Ilhan Alp, Selen Soylu, Serdar Ceylaner, Serhat Ozkan, Sevda Erer Ozbek, Sevgin Gundogan, Sevil Yasufli, Sezin Alpaydin Baslo, Sibel Ertan, Sultan Cagirici, Seyma Aykac, Vuslat Yilmaz, Yaprak Secil, Yasar Kutukcu, Yeliz Ciftci, Yesim Sucullu Karadag, Yildiz Değirmenci, Zeliha Matur, Nerses Bebek, Murat Emre, Zuhal Yapici   +95 more
wiley   +1 more source

Consideration of the restriction of lateral contraction in the elastic behaviour of cohesive zone models

, 2015
Cohesive zone models do not consider the lateral contraction of adhesive layers under tensile loads. The constraint of the lateral contraction by the adherents which depends on the geometry of the adhesive layer has a major influence on the normal ...
Hesebeck, Olaf
core   +1 more source

Higher Amyloid and Tau Burden Is Associated With Faster Decline on a Digital Cognitive Test

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective A 2‐min digital clock‐drawing test (DCTclock) captures more granular features of the clock‐drawing process than the pencil‐and‐paper clock‐drawing test, revealing more subtle deficits at the preclinical stage of Alzheimer's disease (AD). A previous cross‐sectional study demonstrated that worse DCTclock performance was associated with
Jessie Fanglu Fu, Talia Robinson, Marina Rodriguez Alonso, Adela Francis Malave, Roos J. Jutten, Michael J. Properzi, Brian C. Healy, Jackson C. Thompson, Grace Del Carmen Montenegro, Emma Thibault, Dana Penney, Randall Davis, Reisa A. Sperling, Kathryn V. Papp, Keith A. Johnson, Julie C. Price, Dorene M. Rentz   +16 more
wiley   +1 more source

Force Performance Analysis of Pile Behavior of the Lateral Load

Infrastructures, 2019
This study was focused on the performance of the pile force at the lateral load of an arched bridge. The effect of the compression of arch bridges creates a large horizontal load.
Touré Youssouf, Tianlai Yu, Dembélé Abdramane, Assogba Ogoubi Cyriaque, Diakité Youssouf   +4 more
doaj   +1 more source

Bipedal Static Supination and Dynamic Forefoot Loading Characteristics in Taiwanese College Badminton Players: A Cross-Sectional Study

Bioengineering, 2023
Context: Badminton is a unilateral sport that involves repetitive jumping, lunging and quick changes of direction with the lower limb, thus, plantar pressure profiles and foot postural profiles are critical to maintaining balance and coordination ...
Tong-Hsien Chow, Chin-Chia Hsu, Chih-Cheng Chen, Chin-Hsien Hsu   +3 more
doaj   +1 more source

Evaluation of the Spherical Flange Concept for a Rocket Engine [PDF]

, 2003
Due to the inherent tolerance variability of hardware, flange misalignments occur during installation of mating components for a liquid propellant rocket engine. Flange misalignments include axial, lateral, and angular offsets. If these misalignments are
Nichols, Jay, Stangeland, Maynard L., Tygielski, Philip, Urquidi, Ronald   +3 more
core   +1 more source

Standardized loads acting in knee implants [PDF]

, 2014
The loads acting in knee joints must be known for improving joint replacement, surgical procedures, physiotherapy, biomechanical computer simulations, and to advise patients with osteoarthritis or fractures about what activities to avoid. Such data would
Bender, Alwina, Bergmann, Georg, Dymke, Joern, Graichen, Friedmar, Heller, Markus O., Kutzner, Ines, Rohlmann, Antonius, Trepczynski, Adam   +7 more
core   +2 more sources