Results 101 to 110 of about 1,259,675 (344)

Single‐Cell Mitochondrial Lineage Tracing Decodes Fate Decision and Spatial Clonal Architecture in Human Hematopoietic Organoids

open access: yesAdvanced Science, EarlyView.
This study repurposes mitochondrial DNA mutations as endogenous barcodes for lineage tracing in human pluripotent stem cell‐derived organoids. Integrated with transcriptomic and spatial data, it reveals NOTCH‐mediated stromal‐progenitor crosstalk orchestrates clonal dynamics and spatial zonation during early hematopoietic development, offering a non ...
Yan Xue   +17 more
wiley   +1 more source

White matter hyperintensity tissue property spatial variations as a function of cognitive status in Parkinson’s disease

open access: yesNeuroImage
Background and purpose: The pathological relationship between white matter hyperintensities (WMH) and cognitive impairment in Parkinson's disease (PD) remains unclear due to their variable locations, heterogeneity, and limited assessment of underlying ...
Mariyemuguli Reheman   +13 more
doaj   +1 more source

Preterm neonatal lateral ventricle volume from three-dimensional ultrasound is not strongly correlated to two-dimensional ultrasound measurements [PDF]

open access: hybrid, 2016
Jessica Kishimoto   +5 more
openalex   +1 more source

Leucine‐Dependent SLC7A5–PGAM5 Interaction Promotes Advanced Atherosclerosis Through Hindering Mitochondrial Function of Macrophages

open access: yesAdvanced Science, EarlyView.
Higher plasma leucine is associated with increased risk of new‐onset myocardial infarction. Leucine deprivation alleviates advanced atherosclerosis in mice. Tumor‐induced leucine deprivation reprograms macrophage metabolism and increases CD5Lhi macrophages in mouse plaques. Mechanistically, leucine deficiency reduced SLC7A5‐PGAM5 binding in macrophages,
Shan Zhong   +22 more
wiley   +1 more source

Anti-NMDAR encephalitis with euthyroid sick syndrome and lateral ventricle lesions predicts a poor prognosis [PDF]

open access: green, 2022
Gong Wang   +6 more
openalex   +1 more source

Microgel‐Based Hierarchical Porous Hydrogel Patch with Adhesion and Resilience for Myocardial Infarction

open access: yesAdvanced Science, EarlyView.
This study develops a hierarchically porous hydrogel patch strategy (HPMP), based on gas‐shearing microfluidics and an aqueous two‐phase system to fabricate porous microgels as microgel‐based bioinks. The porous microgels with controllable porous structure exhibit excellent cellular behavior.
Ziyang Liu   +13 more
wiley   +1 more source

Detection of Alzheimer’s Disease Using Hybrid Meta-ROI of MRI Structural Images

open access: yesDiagnostics
Background: The averaged cortical thickness of meta-ROI is currently being used for the diagnosis and prognosis of Alzheimer’s disease (AD) using structural MRI brain images.
Xiaoming Zheng   +1 more
doaj   +1 more source

Tumor Extracellular Vesicles lncOSLMT Drives Lung Inflammatory Premetastatic Niche Formation in Osteosarcoma via m6A‐Dependent hnRNPA2B1/COX‐2 Axis

open access: yesAdvanced Science, EarlyView.
Tumor‐derived extracellular vesicles program inflammatory lung premetastatic niches through selective delivery of long noncoding RNAs. This work reveals EVs‐associated lncOSLMT as a key driver of lung fibroblast activation via m6A‐dependent PTGS2 stabilization.
Hongbo Li   +10 more
wiley   +1 more source

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