Results 41 to 50 of about 383 (261)

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Dynamic p-y Model for Laterally Loaded Piles near Clay Slope

Applied Sciences
Seismic loading can significantly affect the safety and serviceability of structures supported by piles, making seismic performance a key consideration in pile foundation design.
Chong Jiang, Yunfei Zhang, Ziqian Ding, Fanhuan Zeng   +3 more
doaj   +1 more source

Nonlinear Predictive Framework of the Undrained Clay Slope Effect on the Initial Stiffness of p-y Curves of Laterally Loaded Piles by FEM

Journal of Marine Science and Engineering, 2022
The hyperbolic p-y curve method is commonly used to design laterally loaded piles, in which the initial stiffness is one of the two key parameters that need to be determined.
Li Pang, Chong Jiang, Lujie Chen
doaj   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Simplified Design Method of Laterally Loaded Rigid Monopiles in Cohesionless Soil

Journal of Marine Science and Engineering
This paper presents a simplified design method for laterally loaded rigid monopiles in cohesionless soil. The proposed design method is based on a constant depth of the rotation point and a bi-linear distribution of soil lateral reaction along the ...
Ruping Luo, Anhui Wang, Jie Li, Wenyun Ding, Bitang Zhu   +4 more
doaj   +1 more source

White Matter Microstructural Abnormalities in Neonatal Onset Genetic Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Recent evidence indicates that epilepsy is associated with abnormal white matter. If seizures alter white matter, then the impact upon network function, epileptogenesis, and cognition could be pronounced in neonates undergoing rapid developmental myelination. Neonates with epilepsy due to nonstructural genetic causes provide a unique
Amanda G. Sandoval Karamian, Tianjia Zhu, Hao Huang, Shavonne L. Massey, Mark P. Fitzgerald, Darshana Parikh, Arastoo Vossough, Ingo Helbig, Nicholas S. Abend   +8 more
wiley   +1 more source

Nonlinear Finite Element Analysis of Laterally Loaded Piles in Cohesive Sediments [PDF]

Engineering and Technology Journal, 2010
Laterally loaded single piles are usually analyzed by methods deriveddirectly from the classical beam on elastic foundation or Winkler soil model. Soilstrength is characterized using modulus of sub-grade reaction.Early solutions that employed Winkler’s ...
Tahsin M. Toma
doaj   +1 more source

Analytical Solution of Laterally Loaded Free-Head Long Piles in Elasto-Plastic Cohesive Soils

Mathematics, 2021
This research study presents a closed form solution of responses of laterally loaded long piles embedded on cohesive soils with a constant subgrade modulus. The surrounding soil medium is modelled as elastic-perfectly plastic. The closed form solution is
Ayman Abd-Elhamed
doaj   +1 more source

Characterization of Defect Distribution in an Additively Manufactured AlSi10Mg as a Function of Processing Parameters and Correlations with Extreme Value Statistics

Advanced Engineering Materials, EarlyView.
Predicting extreme defects in additive manufacturing remains a key challenge limiting its structural reliability. This study proposes a statistical framework that integrates Extreme Value Theory with advanced process indicators to explore defect–process relationships and improve the estimation of critical defect sizes. The approach provides a basis for
Muhammad Muteeb Butt, Varma Kvvssn, Hossein Laieghi, Zia Uddin, Peyman Ansari, E. Kıvanç Sadak, Can Barış Toprak, Hüseyin Kızıl, Enrico Salvati   +8 more
wiley   +1 more source

Case study and practical analysis of lateral bearing characteristics of a single pile in Taihu soft soils using CPTU data

Yantu gongcheng xuebao, 2018
The muddy silty clay is rich in organic matter and widely distributed in Taihu soft soil foundation. It has a large water content and compressibility and is in a state of flow plasticity. All of these make it have bad engineering properties.
LI Hong-jiang 1,2, LIU Song-yu 1,2, TONG Li-yuan 1,2, HA Si 1,2, YANG Wan-yong 3
doaj   +1 more source