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Subfractions of Human Gamma Globulin as Reactant in the Latex Fixation Test
SummaryThe human gamma globulin preparation studied in this investigation was dissolved in diluted phosphate buffer pH = 8.15 and divided into 3 subfractions by stepwise elution from anion-exchange cellulose. These showed different mean migration rate in starch gel electrophoresis. In conformity with the original preparation the subfractions were found
H. Hedberg, U Moritz
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The use of uniform size polystyrene latex particles as substitutes for red blood cells in the serologic test for rheumatoid arthritis has been reported on previously. 1 These biologically inert particles might agglutinate spontaneously without added gamma globulin in the presence of strongly positive rheumatoid serum, but only in a low titer.
Jacques M. Singer
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A Trial of the Latex Fixation Test for Rheumatoid Arthritis
Since the introduction of the differential sheep cell agglutination test by Rose and his associates in 1948, there has been increasing interest in serologic reactions in rheumatoid arthritis. The latex fixation test described by Singer and Plotz' has been applied by Thomas and his associates and modified by Rheins and his associates.
Robert M. Pike+3 more
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A Clinical and Serologic Study of the Latex Fixation Test in Leprosy.
Excerpt While studying the latex fixation test in patients with nonrheumatic diseases, positive reactions were noted in a large proportion of leprosy sera.
E S Cathcart
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The latex fixation test in rheumatic diseases
Jacques M. Singer
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A card test, designed to simplify performance of the latex fixation test on serum, was evaluated by comparison with the standard latex fixation test (technic of Singer and Plotz6). Both tests were made on 152 sera from patients with rheumatoid arthritis and 145 sera from patients with cirrhosis. Results of both the card test and the latex fixation test
Peter Bayless+3 more
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Studies on the Latex-Fixation Test.
Acta Rheumatologica Scandinavica, 1958SummaryThe latex-fixation titer was determined in whole serum and in the euglobulin fraction of serum from patients with rheumatoid arthritis and from control subjects. In the patients with rheumatoid arthritis and joint symptoms for about one year or less the latex-fixation titer was more often found to be positive in the euglobulin fraction than in ...
H. Hedberg
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The effects of serum complement and its components on the rheumatoid latex fixation test [PDF]
AbstractIn the application of the rheumatoid latex fixation test, agglutination may fail to occur in the presence of high concentrations of positive sera in a pattern resembling the prozone of some antigenâantibody reactions. The serum factors responsible for the prozone phenomenon in the rheumatoid latex fixation test have the properties of the second
Ralph J. Wedgwood+2 more
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Quality Control of the Latex-fixation Test
American Journal of Clinical Pathology, 1979Standardization of the latex-fixation test for the detection of rheumatoid factor may be achieved by the preparation of a standard reference serum. A number of guidelines for the quality control of precision and sensitivity of the test are suggested.
Jacques M. Singer+3 more
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A modification of the latex-fixation test for the study of rheumatoid arthritis.
The Journal of laboratory and clinical medicine, 1957Abstract A "drop" modification of the latex-fixation test for the serologic study of sera from patients ill with rheumatoid arthritis was described. The results obtained with this modification apparently are in general agreement with those reported by other investigators who employed a macromethod.
Francis W. McCoy+3 more
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