Results 1 to 10 of about 1,174,109 (58)

Pull-Down Assay-Guided Insights into the Effects of Latroeggtoxin-VI on Nerve Cells [PDF]

Toxins, 2021
Latroeggtoxin-VI (LETX-VI) is a peptide neurotoxin newly found from the eggs of spider L. tredecimguttatus. To explore the mechanism of action of the LETX-VI on nerve cells, the effects of LETX-VI on PC12 cells, a commonly used neuron model, were ...
Xianchun Wang, Yiwen Zhai, Zhixiang Lei   +2 more
exaly   +5 more sources

Analysis of differentially expressed genes discovers Latroeggtoxin VI-induced changes and SYNJ1 as a main target in PC12 cells [PDF]

BMC Genomics, 2023
Background Previous preliminary work found that Latroeggtoxin-VI (LETX-VI), a proteinaceous neurotoxin from the eggs of spider Latrodectus tredecimguttatus, could promote the synthesis and release of dopamine in PC12 cells.
Xianchun Wang, Minglu Sun, Yiwen Zhai
exaly   +4 more sources

Latroeggtoxin-VI protects nerve cells and prevents depression by inhibiting NF-κB signaling pathway activation and excessive inflammation [PDF]

Frontiers in Immunology, 2023
Depression has a high incidence and seriously endangers human health. Accumulated evidence indicates that targeting neuroinflammation is a potential avenue for neuroprotection and thus depression prevention.
Zhigui Duan, Xianchun Wang, Minglu Sun   +2 more
exaly   +4 more sources

Effects of latroeggtoxin-VI on dopamine and α-synuclein in PC12 cells and the implications for Parkinson’s disease [PDF]

Biological Research
Background Parkinson’s disease (PD) is characterized by death of dopaminergic neurons leading to dopamine deficiency, excessive α-synuclein facilitating Lewy body formation, etc.
Xianchun Wang, Minglu Sun, Yiwen Zhai
exaly   +3 more sources

Recent Advances in Research on Widow Spider Venoms and Toxins [PDF]

Toxins, 2015
Xianchun Wang
exaly   +2 more sources

Latroeggtoxin-VI improves depression by regulating the composition and function of gut microbiota in a mouse model of depression [PDF]

Journal of Medical Microbiology
Zhigui Duan, Xianchun Wang, Minglu Sun   +2 more
exaly   +2 more sources

Insights into the mediation of Ca²⁺ signaling in the promoting effects of LETX-VI on the synthesis and release of dopamine. [PDF]

J Cell Commun Signal, 2023
Lei Z, Wang H, Zhai Y, Sun M, Chen S, Yin P, Wang X.   +6 more
europepmc   +1 more source

Spider-Venom Peptides: Structure, Bioactivity, Strategy, and Research Applications. [PDF]

Molecules, 2023
Guo R, Guo G, Wang A, Xu G, Lai R, Jin H.   +5 more
europepmc   +1 more source

Synaptotagmin 1-mediated cell membrane penetration and dopamine release enhancement by latroeggtoxin-VI

International Journal of Biological Macromolecules, 2022
Minglu Sun, Yiwen Zhai, Zhixiang Lei
exaly  

Biochemical and cytotoxic evaluation of latroeggtoxin‐VI against PC12 cells

Journal of Biochemical and Molecular Toxicology, 2021
Xianchun Wang
exaly