PC12 Cell Line: Cell Types, Coating of Culture Vessels, Differentiation and Other Culture Conditions [PDF]
Cells, 2020 The PC12 cell line is one of the most commonly used in neuroscience research, including studies on neurotoxicity, neuroprotection, neurosecretion, neuroinflammation, and synaptogenesis.
Benita Wiatrak +3 more
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Optimisation of a PC12 cell-based in vitro stroke model for screening neuroprotective agents [PDF]
Scientific Reports, 2021 Stroke causes death and disability globally but no neuroprotectant is approved for post-stroke neuronal injury. Neuroprotective compounds can be identified using oxygen glucose deprivation (OGD) of neuronal cells as an in vitro stroke model. Nerve growth
PinFen Chua, William K. Lim
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Optogenetic Delineation of Receptor Tyrosine Kinase Subcircuits in PC12 Cell Differentiation. [PDF]
Cell Chem Biol, 2019 Summary Nerve growth factor elicits signaling outcomes by interacting with both its high-affinity receptor, TrkA, and its low-affinity receptor, p75NTR.
Khamo JS +4 more
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Peroxynitrite nitration of Tyr 56 in Hsp90 induces PC12 cell death through P2X7R-dependent PTEN activation [PDF]
Redox Biology, 2022 The diffusion-limited reaction of nitric oxide (NO) and superoxide (O2−) produces peroxynitrite (ONOO−), a biological oxidant that has been implicated in a number of pathological conditions, including neurodegenerative disorders.
Megan Jandy +17 more
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Adipose Mesenchymal Stem Cell-Derived Exosomes Enhance PC12 Cell Function through the Activation of the PI3K/AKT Pathway [PDF]
Stem Cells International, 2021 Transplantation of mesenchymal stem cells has been considered as an auspicious treatment for repairing nerve injuries. The rat adrenal pheochromocytoma cell line (PC12) is one of the traditional models for the study of neuronal differentiation and ...
Yong Xie +5 more
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Dimethyloxalylglycine (DMOG), a Hypoxia Mimetic Agent, Does Not Replicate a Rat Pheochromocytoma (PC12) Cell Biological Response to Reduced Oxygen Culture [PDF]
Biomolecules, 2022 Cells respond to reduced oxygen availability predominately by activation of the hypoxia-inducible factor (HIF) pathway. HIF activation upregulates hundreds of genes that help cells survive in the reduced oxygen environment.
RuoLi Chen +2 more
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Differentiating PC12 cells to evaluate neurite densities through live-cell imaging [PDF]
STAR Protocols, 2023 Summary: Although PC12 cells are a valuable tool in neuroscience research, previously published PC12 cell differentiation techniques fail to consider the variability in differentiation rates between different PC12 cell strains and clonal variants.
Jordyn Karliner, Diane E. Merry
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Artificial Cells, Nanomedicine, and Biotechnology, 2020 Background Protocatechuic aldehyde (PA) extracts from S. miltiorrhiza, which anti-oxidative and anti-inflammatory functions have been certified in diverse diseases. Nonetheless, the influence of PA in spinal cord injury (SCI) is still hazy.
Zhiwei Zhong +6 more
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Neural Regeneration Research, 2020 Mitochondrial dysfunction in neurons has been implicated in hypoxia-ischemia-induced brain injury. Although mesenchymal stem cell therapy has emerged as a novel treatment for this pathology, the mechanisms are not fully understood. To address this issue,
Yan Yang +7 more
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Applied Bionics and Biomechanics, 2022 Background. In recent years, the incidence of depression is on the rise. Our paper proposed to study the protective effects of Schisandrin on CORT-induced PC12 depressive cell model and the underlying mechanisms. Methods. The in vitro models of PC12 were
Liu Yang +8 more
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