Results 1 to 10 of about 4,447,834 (239)
Characterization of intermediate filaments in PC12 cells [PDF]
The Journal of Neuroscience, 1987 A 57 kDa protein is the major polypeptide in intermediate filament (IF)- enriched cytoskeletal preparations obtained from the neuronal cell line PC12 (rat pheochromocytoma). Under the conditions used to assemble IF in vitro from other cultured cell lines, 10 nm filaments are formed after 2 cycles of disassembly-assembly from PC12 IF-enriched ...
L M, Parysek, R D, Goldman
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Response to Oxidative Stress Induced by Octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine in Differentiated PC12 Cells [PDF]
ToxicsOctahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine (HMX) is a globally recognized energetic material that widely used in industrial, mining, and military fields. Like hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) and other nitramine compounds, HMX has also
Cunzhi Li +9 more
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Gypenosides Attenuates CORT-Induced Ferroptosis via Inhibiting TNF-α/NF-κB Signaling Pathway in PC12 Cells [PDF]
MoleculesChronic stress can lead to nervous system dysfunction and depression-like behaviors in animals. Gypenosides can improve chronic stress-induced neuronal damage, but the protective mechanism remains poorly understood.
Lingling Dai +7 more
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miR-96-5p is involved in alcohol-induced apoptosis in PC12 cells via negatively regulating TAp73
PLoS ONE, 2023 Objective The present study opted for the adrenal phaeochromocytoma (PC12) cell line to frame a neuronal injury model induced by alcohol exposure in vitro, aiming to probe whether TAp73 and miR-96-5p are involved in the neuronal injury process induced by
Bin Yang +8 more
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The PC12 cell as model for neurosecretion [PDF]
Acta Physiologica, 2007 AbstractThis review attempts to touch on the history and application of amperometry at PC12 cells for fundamental investigation into the exocytosis process. PC12 cells have been widely used as a model for neural differentiation and as such they have been used to examine the effects of differentiation on exocytotic release and specifically release at ...
Westerink, R.H.S., Ewing, A.G.
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Optimisation of a PC12 cell-based in vitro stroke model for screening neuroprotective agents
Scientific Reports, 2021 Stroke causes death and disability globally but no neuroprotectant is approved for post-stroke neuronal injury. Neuroprotective compounds can be identified using oxygen glucose deprivation (OGD) of neuronal cells as an in vitro stroke model. Nerve growth
PinFen Chua, William K. Lim
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NeuroSci, 2021 Previous research has demonstrated that pheochromocytoma (PC12) cells treated with forskolin provides a model for the in vitro examination of neuritogenesis.
Trevor N. Carniello +2 more
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Neural Regeneration Research, 2020 Mitochondrial dysfunction in neurons has been implicated in hypoxia-ischemia-induced brain injury. Although mesenchymal stem cell therapy has emerged as a novel treatment for this pathology, the mechanisms are not fully understood. To address this issue,
Yan Yang +7 more
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Scientific Reports, 2022 Dp40 is ubiquitously expressed including the central nervous system. In addition to being present in the nucleus, membrane, and cytoplasm, Dp40 is detected in neurites and postsynaptic spines in hippocampal neurons.
César García-Cruz +6 more
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Calcium Regulation of Exocytosis in PC12 Cells [PDF]
Journal of Biological Chemistry, 2001 The calcium (Ca(2+)) regulation of neurotransmitter release is poorly understood. Here we investigated several aspects of this process in PC12 cells. We first showed that osmotic shock by 1 m sucrose stimulated rapid release of neurotransmitters from intact PC12 cells, indicating that most of the vesicles were docked at the plasma membrane.
Y A, Chen +6 more
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