Results 11 to 20 of about 4,447,834 (239)
Folia Neuropathologica, 2023 Alzheimer’s disease (AD), the most common contributor to dementia, is a growing global health problem. This study aimed to investigate the role of lemur tyrosine kinase 2 (LMTK2) in AD as well as its relevant mechanism.
Lili Zhang, Fei Shu
doaj +2 more sources
Fucosyl gangliosides of PC12 pheochromocytoma cells [PDF]
FEBS Letters, 1984 Three monosialogangliosides are highly labeled when PC12 pheochromocytoma cells are cultured in the presence of L‐[3H] fucose, and two additional monosialogangliosides are labeled to a lesser extent. In contrast, neither of the two disialogangliosides of PC12 cells contains fucose residues.
Margolis, R.U. +3 more
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Aspartame-induced apoptosis in PC12 cells [PDF]
Environmental Toxicology and Pharmacology, 2014 Aspartame is an artificial sweetner added to many low-calorie foods. The safety of aspartame remains controversial even though there are many studies on its risks. In this study, to understand the physiological effects of trace amounts of artificial sweetners on cells, the effects of aspartame on apoptosis were investigated using a PC12 cell system. In
Horio, Yukari +4 more
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Evaluation of Reaction of Primate Brain to Grafted PC12 Cells
Cell Transplantation, 1999 Intrastriatal implantation of polymer-encapsulated PC12 cells, which constitute a dopaminergic cell line derived from rat pheochromocytoma, has proved useful for ameliorating parkinsonian symptoms in several kinds of animals.
Hideyuki Yoshida M.D. +6 more
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Ceramide induces apoptosis in PC12 cells [PDF]
FEBS Letters, 1997 The novel lipid second messenger, ceramide, induced apoptosis in PC12 cells as determined morphologically by nuclear appearance and internucleosomal DNA fragmentation. Apoptosis was induced by exogenous C2‐ceramide in a dose‐ and time‐dependent manner. Natural ceramide and C6‐ceramide had a similar effect.
Hartfield, Perry J +2 more
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Calcium Transport Mechanisms of PC12 Cells [PDF]
The Journal of Cell Biology, 2008 Many studies of Ca2+ signaling use PC12 cells, yet the balance of Ca2+ clearance mechanisms in these cells is unknown. We used pharmacological inhibition of Ca2+ transporters to characterize Ca2+ clearance after depolarizations in both undifferentiated and nerve growth factor-differentiated PC12 cells.
Duman, Joseph G. +2 more
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Artificial Cells, Nanomedicine, and Biotechnology, 2020 Background Protocatechuic aldehyde (PA) extracts from S. miltiorrhiza, which anti-oxidative and anti-inflammatory functions have been certified in diverse diseases. Nonetheless, the influence of PA in spinal cord injury (SCI) is still hazy.
Zhiwei Zhong +6 more
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Introduction of Macromolecules into Bovine Adrenal Medullary Chromaffin Cells and Rat Pheochromocytoma Cells (PC12) by Permeabilization with Streptolysin O: Inhibitory Effect of Tetanus Toxin on Catecholamine Secretion [PDF]
, 1989 Conditions are described for controlled plasma membrane permeabilization of rat pheochromocytoma cells (PC12) and cultured bovine adrenal chromaffin cells by Streptolysin O (SLO).
Ahnert-Hilger, G. +3 more
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Rab3D is critical for secretory granule maturation in PC12 cells. [PDF]
, 2013 Neuropeptide- and hormone-containing secretory granules (SGs) are synthesized at the trans-Golgi network (TGN) as immature secretory granules (ISGs) and complete their maturation in the F-actin-rich cell cortex.
Sharon A. Tooze (391543) +36 more
core +1 more source
Memantine inhibits 6-OHDA-induced apoptosis PC12 cells via the Nurr77 and caspase pathway
Asian Pacific Journal of Tropical Medicine, 2019 Objective: To investigate the effect of memantine on Parkinson’s disease cell models. Methods: Parkinson’s disease cell models were established using PC12 cells incubated with 6-hydroxydopamine (6-OHDA).
Wei Wu +5 more
doaj +1 more source