Results 141 to 150 of about 220,829 (195)

Proteomic profiling of Elp1‐deficient trigeminal ganglia reveals disruption of neurotrophic and metabolic pathways in a familial dysautonomia mouse model

Developmental Dynamics, EarlyView.
Abstract Background Elp1, a subunit of the Elongator complex, is essential for tRNA modification and neuronal development. Mutations in ELP1 underlie familial dysautonomia (FD), a disorder marked by sensory and autonomic neuropathy. While loss of Elp1 disrupts trigeminal ganglion formation and survival, the downstream molecular consequences remain ...
Carrie E. Leonard, Lauren Clarissa Tang, Beatrix Ueberheide, Lisa A. Taneyhill   +3 more
wiley   +1 more source

Empirically Defining “Recurrent” Inappropriate Compensatory Behaviors: Differentiating Binge Eating Disorder From Bulimia Nervosa‐Spectrum Disorders

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective For multiple disorders, DSM‐5‐TR criteria include “recurrent” engagement in behaviors—for example, in the criteria for binge‐eating disorder (BED), “binge eating is not associated with the recurrent use of inappropriate compensatory behavior.”—without operationalizing how frequently a behavior needs to occur to be considered ...
Sophie R. Abber, Dan V. Blalock, Renee D. Rienecke, Philip S. Mehler, Alan Duffy, Jamie Manwaring, Maryrose Bauschka, Kimberly Anderson, Harry A. Brandt, Craig Johnson, Timothy Brewerton, Thomas E. Joiner, Lauren N. Forrest   +12 more
wiley   +1 more source

Synthesis of S‐Linked Glycoconjugates of Monosaccharides and Levoglucosenone Derivatives Through Photoinduced Thiol–Ene Reaction Mediated by 4CzIPN and Its Water Soluble Analog

European Journal of Organic Chemistry, EarlyView.
Visible‐light thiol–ene reaction mediated by 4CzIPN enables access to hydrolytically stable S‐linked glycoconjugates from levoglucosenone‐derived thiols (Y = 91% to quant. d.r. = up to >95:5) and conventional thio‐sugars (Y = 80% to quant. d.r. = up to >95:5).
Lorenzo Poletti, Francesco Riina, Daniele Ragno, Carmela De Risi, Alessandro Massi, Graziano Di Carmine   +5 more
wiley   +1 more source

Abstracts from the 2017 Society of General Internal Medicine Annual Meeting. [PDF]

J Gen Intern Med, 2017
europepmc   +1 more source

Synthesis of α‐C‐Glycoside Conjugates Promoted by 4CzIPN‐Based Porous Organic Polymers Through Giese‐Like Reaction of Glycosyl Bromides in Batch and Continuous Flow

European Journal of Organic Chemistry, EarlyView.
Visible light and a 4CzIPN‐based porous organic polymer (4CzIPN‐POP) enable Giese‐like coupling of glycosyl bromides with electron‐poor alkenes to access α‐C‐glycoside conjugates. The study shows how heterogeneous thermally activated delayed fluorescence photocatalysis can be combined with continuous flow to overcome light penetration limits and ...
Francesco Riina, Laura Manfrin, Lorenzo Poletti, Daniele Ragno, Carmela De Risi, Alessandro Massi, Graziano Di Carmine   +6 more
wiley   +1 more source

Predicting levetiracetam neuropsychiatric adverse effects using graph‐theoretical electroencephalographic network metrics in drug‐naive focal epilepsy: A multicenter longitudinal study

Epilepsia, EarlyView.
Abstract Objective Levetiracetam (LEV) is an antiseizure medication approved for focal and generalized epilepsy. Despite its efficacy, neuropsychiatric adverse effects (NP‐AEs) may lead to treatment discontinuation. Quantitative electroencephalographic (qEEG) graph‐theoretical analysis has emerged as a valuable tool for identifying neurophysiological ...
Marco Sferruzzi, Lorenzo Ricci, Margherita Anna Grazia Matarrese, Francesca Izzi, Fabio Placidi, Biagio Maria Sancetta, Emanuele Cerulli Irelli, Patrizia Pulitano, Vincenzo Di Lazzaro, Mario Tombini, Giovanni Assenza   +10 more
wiley   +1 more source

Abstracts of the 62nd Annual Scientific Meeting, March 26-28, 2015, San Francisco, California. [PDF]

Reprod Sci, 2015
europepmc   +1 more source

Classifying seizures in practice: Testing the 2025 ILAE framework among clinicians in South Africa

Epilepsia, EarlyView.
Abstract Objective The 2025 International League Against Epilepsy (ILAE) seizure classification introduced a basic version for nonspecialists, but its usability is untested. We evaluated whether a multidisciplinary frontline workforce in South Africa could apply it, how consistently, and whether performance improved after self‐directed exposure ...
Aayesha J. Soni, Sarah Jacobs, Muhammad Ilyaas Amien, Abdullah J. Soni, Faeeza Cassim, Sa'ad Lahri, Naeem Brey, Misha Janse van Rensburg, Avumile Nongogo Futwa, Johnre Els, Keashe Adams, Bilal Irfan, M. Claudia Burbano, Jorge G. Burneo   +13 more
wiley   +1 more source

Expanding the electroclinical spectrum of TANC2‐related disorders: Lennox–Gastaut syndrome and related developmental epileptic phenotypes

Epilepsia Open, EarlyView.
Abstract Objective Neurodevelopmental disorders (NDDs) and epilepsy are often associated. Increasing evidence highlights a pivotal role for pathogenic variants in genes encoding synaptic scaffolding proteins. Within this group, TANC2 has recently been implicated in intellectual developmental disorder with autistic features and language delay, with or ...
Lorenzo Perilli, Carlotta Stipa, Gianmichele Villano, Laura Licchetta, Leo Strothmann, Robin Tobias Jauss, Gerhard Josef Kluger, Raffaella Minardi, NETRE consortium, Giuseppe Gobbi, Salvatore Grosso, Francesca Bisulli, Pasquale Striano   +12 more
wiley   +1 more source

Sudden unexpected death in epilepsy: An Italian expert consensus statement on risk, mechanisms, prevention, and therapeutic strategies

Epilepsia Open, EarlyView.
Abstract Objective Sudden unexpected death in epilepsy (SUDEP) is a leading cause of premature mortality in people with epilepsy, particularly in those with tonic–clonic seizures (TCSs), developmental and epileptic encephalopathies (DEEs), and drug‐resistant epilepsy.
Vincenzo Belcastro, Fedele Dono, Giovanni Falcicchio, Lorenzo Gigli, Angela La Neve, Sara Matricardi, Barbara Mostacci, Angelo Pascarella, Leandro Pecchia, Emilio Russo, Pasquale Striano   +10 more
wiley   +1 more source