Results 31 to 40 of about 166,480 (215)

OUTLINE OF A GENERAL THEORY OF SYSTEMIC CONSTITUCIONALISM FOR WORLD SOCIETY

open access: yesRevista Eletrônica Direito e Política, 2020
The present article aims to present to academic community the outline of a general theory of systemic constitutionalism. The method used was the functionalist, based on Niklas Luhmann’s theory of autopoietic systems. The instrumental (technical) research
Fernando Tonet   +1 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

open access: yesMolecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur   +11 more
wiley   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

open access: yesFEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya   +2 more
wiley   +1 more source

IgA-Based Secretory Response in Tears of COVID-19 Patients: A Potential Biomarker of Pro-Inflammatory State in Course of SARS-CoV-2 Infection

open access: yesPathogens, 2022
Mucosal immunity, including secretory IgA (sIgA), plays an important role in the early defence against SARS-CoV-2 infection. However, a comprehensive evaluation of the local immune response in tears in relation to blood antibody reservoirs has not yet ...
Anna Niedźwiedź   +8 more
doaj   +1 more source

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

open access: yesFEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito   +7 more
wiley   +1 more source

The Impact of EU Accession on the Development of Administrative Capacities in the States in Central and Eastern Europe. Similar Developments in Russia? [PDF]

open access: yesRomanian Journal of European Affairs, 2006
The developments of the civil service and administrative reform in Central and Easter European countries and in Russia are more or less similar. For the Central and Eastern European countries explicitly EU Membership is mentioned as an incentive for ...
Alfred E. Kellermann
doaj  

Optimizing photoexcitation conditions for time‐resolved X‐ray solution scattering experiments

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering (TR‐XSS) is a powerful technique to visualize how proteins change their structure in real time after light activation. Selecting the right laser photoexcitation conditions—fluence, excitation geometry, and sample refresh rate—is critical to maximize the experimental signal while avoiding unwanted side effects ...
Matteo Levantino
wiley   +1 more source

EMU in the Case Law of the Union Courts: A General Overview and Some Observations

open access: yesEuropean Papers, 2022
(Series Information) European Papers - A Journal on Law and Integration, 2021 6(3), 1397-1414 | Article | (Table of Contents) I. Introduction. - II. Four main categories of CJEU cases. - II.1. EMU and the euro and debt crisis in general. - II.2. Problems
Allan Rosas
doaj   +1 more source

Effectiveness of rTMS on Working Memory and Inhibitory Impairments in Patients With Post‐Stroke Executive Deficits

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Considerable efforts have been dedicated to developing effective treatments for post‐stroke executive impairment (PSEI), among which repetitive transcranial magnetic stimulation (rTMS) has shown great potential. This study aimed to investigate the therapeutic effects of high‐frequency rTMS on working memory (WM) and response ...
Mengting Lao   +6 more
wiley   +1 more source

Precautionary in International Law: A Customary Principle or a General Principle of Law? [PDF]

open access: yesFaṣlnāmah-i Pizhūhish-i Huqūq-i ̒Umūmī, 2018
It took humankind a long time to realize its inability to understand different aspects of environmental risks and find that it would bear irreversible damage if such a risk occurs.
Abbasali KadKhodaei, Asma Salari
doaj   +1 more source

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