Results 101 to 110 of about 42,248,976 (243)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

LAYER-BY-LAYER NANOSCALE BONDLINES FOR MACROSCALE ADHESION

BioResources, 2010
The objective of this study was to test the bonding performance of nanoscale bondlines, which were fabricated with polyelectrolytes by layer-by-layer assembly process onto wooden substrates. In this study, environmental scanning electron microscopy (ESEM)
Yu Zhou, Scott Renneckar, Qingqing Li, Karthik V Pillai, Zhiyuan Lin, W Travis Church   +5 more
doaj  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Layer-by-Layer Nanoparticles for Calcium Overload in situ Enhanced Reactive Oxygen Oncotherapy

International Journal of Nanomedicine
Boye Zhang,1,2 Jianliang Man,3,4 Lingyun Guo,1 Xiaoxia Ru,1 Chengwu Zhang,1,2 Wen Liu,1,2,5 Lihong Li,1,2,5 Sufang Ma,1,2 Lixia Guo,2,4 Haojiang Wang,1,2 Bin Wang,1,2 Haipeng Diao,1,5 Renchao Che,6,7 Lili Yan1,2,5 1School of Basic Medical Sciences ...
Zhang B, Man J, Guo L, Ru X, Zhang C, Liu W, Li L, Ma S, Guo L, Wang H, Wang B, Diao H, Che R, Yan L   +13 more
doaj  

Heat Sterilizable Coatings Based on Nafion and Graphene Quantum Dots With Advanced Antibacterial Performance

Nano Select
The study focuses on the preparation of electrostatically assembled layer‐by‐layer waterborne nanocoatings comprising negatively charged Nafion and positively charged imidazole modified‐graphene quantum dots (GQD‐Ims). We demonstrate here that Nafion/GQD‐
Mohammed Suleman Beg, Ella Nicole Gibbons, James Duncalf, Spyridon Gavalas, Daniel Redman, Mark A. Holden, Antonios Kelarakis   +6 more
doaj   +1 more source

Fabrication of hybrid graphene oxide/polyelectrolyte capsules by means of layer-by-layer assembly on erythrocyte cell templates

Beilstein Journal of Nanotechnology, 2015
A novel and facile method was developed to produce hybrid graphene oxide (GO)–polyelectrolyte (PE) capsules using erythrocyte cells as templates. The capsules are easily produced through the layer-by-layer technique using alternating polyelectrolyte ...
Joseba Irigoyen, Nikolaos Politakos, Eleftheria Diamanti, Elena Rojas, Marco Marradi, Raquel Ledezma, Layza Arizmendi, J. Alberto Rodríguez, Ronald F. Ziolo, Sergio E. Moya   +9 more
doaj   +1 more source

Composite hodographs and inertial oscillations in the nocturnal boundary layer

, 2011
In this work the dynamic behaviour of the wind in the nocturnal boundary layer is studied, with a particular focus on systematic behaviour of the near-surface wind.
P. Baas, Wiel, BJH Bas van de, L. van den Brink, A.A.M. Holtslag, Baas, P, van den Brink, L., Wiel, B.J.H., van de, van de Wiel, B.J.H., Wiel, van de, B.J.H., Holtslag, AAM, Holtslag, A.A.M., B. J. H. van de Wiel, Baas, P., Brink, L van den, Brink, van den, L., Brink, L., van den   +15 more
core   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Enhancing Penetration Performance and Drug Delivery of Polymeric Microneedles Using Silica Nanoparticle Coatings

Advanced Materials Interfaces
Microneedle (MN) technology offers a powerful approach for transdermal delivery enabling painless injection and facilitating self‐administration without the need for professional assistance.
Sohyun Kim, Hyewon Choi, Hyejoong Jeong, Wilfredo Méndez Ortiz, Hwayeong Cheon, Jae Yong Jeon, Jae Hyeon Lee, Jeong Hwan Han, Kathleen J. Stebe, Daeyeon Lee, Hyunsik Yoon   +10 more
doaj   +1 more source

Nanostructured Biomaterials with Controlled Properties Synthesis and Characterization

Nanoscale Research Letters, 2009
Magnetic nanoparticles were obtained using an adjusted Massart method and were covered in a layer-by-layer technique with hydrogel-type biocompatible shells, from chitosan and hyaluronic acid.
Petcu C, Somoghi Raluca, Teodor Eugenia, Liţescu SimonaCarmen, Mihalache Mihaela   +4 more
doaj   +1 more source