Results 51 to 60 of about 58,089,591 (242)

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Chitosan/siRNA functionalized titanium surface via a layer-by-layer approach for in vitro sustained gene silencing and osteogenic promotion

International Journal of Nanomedicine, 2015
Wen Song,1,* Xin Song,2,* Chuanxu Yang,2 Shan Gao,2 Lasse Hyldgaard Klausen,2 Yumei Zhang,1 Mingdong Dong,2 Jørgen Kjems21State Key Laboratory of Military Stomatology, Department of Prosthetic Dentistry, School of Stomatology, The Fourth Military ...
Song W, Song X, Yang C, Gao S, Klausen LH, Zhang Y, Dong M, Kjems J   +7 more
doaj  

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Layer-by-layer thermal conductivities of the Group III nitride films in blue/green light emitting diodes

, 2018
Thermal conductivities (k) of the individual layers of a GaN-based light emitting diode(LED) were measured along [0001] using the 3-omega method from 100-400 K.
Li Huang (5371322), Fang Liu (5371331), Lisa Porter (3889522), Robert Davis (3892600), Jonathan Malen (3887539), Zonghui Su (5371325), Justin P. Freedman (5371328)   +6 more
core   +1 more source

Layer-by-Layer Exfoliation of Transition-Metal Dichalcogenides by Amino Acid in Water for Promoting Hydrogen Evolution Reaction

, 2022
Two-dimensional transition-metal dichalcogenides (TMDs) are promising as efficient and earth-abundant electrocatalysts for the hydrogen evolution reaction (HER). However, only the edge and defect sites show HER catalytic properties, while the basal plane,
Guan-Xiang Huang (12323240), I-Wen Peter Chen, I-Wen Peter Chen (2452339), Yen-Hsuan Li, Yuan-Long Su (12323237), Guan-Xiang Huang, Yen-Hsuan Li (12323234), Yuan-Long Su   +7 more
core   +1 more source

Layer-by-layer nanoparticles co-loading gemcitabine and platinum (IV) prodrugs for synergistic combination therapy of lung cancer

Drug Design, Development and Therapy, 2017
Rongrong Zhang, Yun Ru, Yiping Gao, Jinyin Li, Shilong Mao Department of Pharmacy, Shanghai Xuhui District Central Hospital, Zhongshan Hospital Affiliated to Fudan University Xuhui Hospital, Shanghai, People’s Republic of China Purpose: Cisplatin
Zhang R, Ru Y, Gao Y, Li J, Mao S
doaj  

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Layer-by-layer segmentation was executed automatically using the new software for the Spectralis OCT.

, 2019
(A) Nine macular sectors of every single retinal layer in spectral-domain optical coherence tomography. The superior outer macula, superior inner macula, fovea, inferior inner macula and inferior outer macula were used for analysis.
Jih-Pin Lin (6195419), Jen-Chia Tsai (6195425), Ing-Chou Lai (6195422), Pei-Wen Lin (750548)   +3 more
core   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source